Reactome | p-SLP-76 binds VAV

p-SLP-76 binds VAV

Stable Identifier

R-HSA-430158

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SLP-76 is a hematopoietic cell-specific adapter protein. Studies indicate that three phosphotyrosines in SLP-76 (Y113, Y128, and Y145) are required for interactions with the SH2 domains of Vav1 (and Nck and Itk). This interaction is essential for membrane recruitment of Vav1. Similarly, association of Vav3 with SLP-76 was found to be essential for membrane recruitment. Vav2 has been shown to interact with SLP-76 in resting Jurkat cells.

Literature References

PubMed ID	Title	Journal	Year
11262396	Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte Charvet, C, Tartare-Deckert, S, Monthouel, MN, Deckert, M, Altman, A, Bernard, A, Foucault, I, Van Obberghen, E	J Biol Chem	2001
15708849	Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76 Billadeau, DD, Charvet, C, Altman, A, Canonigo, AJ	J Biol Chem	2005
8673706	Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation Motto, DG, Weiss, A, Koretzky, GA, Wu, J	Immunity	1996