p-SLP-76 binds ADAP

Stable Identifier
R-HSA-430135
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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SLP-76 inducibly-associates with ADAP (also known as FYN-binding protein or SLAP-130) a hematopoietic-specific adapter protein. ADAP has been implicated in T cell migration and rearrangement of the actin cytoskeleton. In platelets, adhesion to fibrinogen stimulates the association of SLP-76 with ADAP and VASP (Obergfell et al. 2001). ADAP knockout mice exhibit mild thrombocytopenia (Kasirer-Friede et al. 2007).
Literature References
PubMed ID Title Journal Year
9115214 Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases

Hendricks-Taylor, LR, Musci, MA, Paskind, M, Turck, CW, Kamens, J, Motto, DG, Koretzky, GA

J Biol Chem 1997
10671560 Functional association between SLAP-130 and SLP-76 in Jurkat T cells

Boerth, NJ, Koretzky, GA, Judd, BA

J Biol Chem 2000
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