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EXOSC4 [cytosol]
Stable Identifier
R-HSA-430013
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Exosome complex exonuclease RRP41, EXOS4_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
PERK regulates gene expression (Homo sapiens)
ATF4 activates genes in response to endoplasmic reticulum stress (Homo sapiens)
Expression of IL-8 (Homo sapiens)
KSRP:mRNA Degradation Complex [cytosol] (Homo sapiens)
Exosome Complex [cytosol] (Homo sapiens)
Exosome Ring Hexamer [cytosol] (Homo sapiens)
EXOSC4 [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Deadenylation-dependent mRNA decay (Homo sapiens)
mRNA decay by 3' to 5' exoribonuclease (Homo sapiens)
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Homo sapiens)
Exosome:SKI complex [cytosol] (Homo sapiens)
Exosome Complex [cytosol] (Homo sapiens)
Exosome Ring Hexamer [cytosol] (Homo sapiens)
EXOSC4 [cytosol] (Homo sapiens)
Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA (Homo sapiens)
BRF1 Complex recruits RNA degradation activities (Homo sapiens)
BRF1:mRNA Degradation Complex [cytosol] (Homo sapiens)
Exosome Complex [cytosol] (Homo sapiens)
Exosome Ring Hexamer [cytosol] (Homo sapiens)
EXOSC4 [cytosol] (Homo sapiens)
Exosome Complex [cytosol] (Homo sapiens)
Exosome Ring Hexamer [cytosol] (Homo sapiens)
EXOSC4 [cytosol] (Homo sapiens)
KSRP (KHSRP) binds and destabilizes mRNA (Homo sapiens)
KSRP recruits RNA degradation activities (Homo sapiens)
Exosome Complex [cytosol] (Homo sapiens)
Exosome Ring Hexamer [cytosol] (Homo sapiens)
EXOSC4 [cytosol] (Homo sapiens)
KSRP:mRNA Degradation Complex [cytosol] (Homo sapiens)
Exosome Complex [cytosol] (Homo sapiens)
Exosome Ring Hexamer [cytosol] (Homo sapiens)
EXOSC4 [cytosol] (Homo sapiens)
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA (Homo sapiens)
ZFP36 (TTP) recruits RNA degradation activities (Homo sapiens)
Exosome Complex [cytosol] (Homo sapiens)
Exosome Ring Hexamer [cytosol] (Homo sapiens)
EXOSC4 [cytosol] (Homo sapiens)
TTP:mRNA Degradation Complex [cytosol] (Homo sapiens)
Exosome Complex [cytosol] (Homo sapiens)
Exosome Ring Hexamer [cytosol] (Homo sapiens)
EXOSC4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NPD3 EXOSC4
Gene Names
EXOSC4, RRP41, SKI6
Chain
initiator methionine:, chain:2-245
Reference Genes
BioGPS Gene:54512 EXOSC4
COSMIC (genes):EXOSC4 EXOSC4
CTD Gene:54512 EXOSC4
dbSNP Gene:54512 EXOSC4
ENSEMBL:ENSG00000178896 EXOSC4
ENSEMBL_homo_sapiens_GENE:ENSG00000178896.9 EXOSC4
HGNC:18189 EXOSC4
KEGG Gene (Homo sapiens):54512 EXOSC4
Monarch:54512 EXOSC4
NCBI Gene:54512 EXOSC4
OMIM:606491 EXOSC4
UCSC:Q9NPD3 EXOSC4
Reference Transcript
RefSeq:NM_019037.2 EXOSC4
Other Identifiers
11720077_at
17073527
218695_PM_at
218695_at
3120009
3120010
3120015
3120016
3120017
3120018
54512
58696_PM_at
58696_at
8148710
91684_PM_g_at
91684_g_at
A_23_P32463
A_33_P3301410
GE55565
GO:0000175
GO:0000176
GO:0000177
GO:0000178
GO:0000460
GO:0000791
GO:0000956
GO:0003723
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0006364
GO:0006396
GO:0006401
GO:0016071
GO:0016073
GO:0016075
GO:0016787
GO:0030307
GO:0034427
GO:0034475
GO:0035925
GO:0042254
GO:0043226
GO:0043231
GO:0045006
GO:0051607
GO:0071028
GO:0071044
GO:0071051
GO:0098542
GO:0101019
GO:0140098
HMNXSV003025819
ILMN_1745271
PH_hs_0016640
PH_hs_0032744
TC08000838.hg
g9506688_3p_at
g9506688_3p_s_at
Participates
as a component of
Exosome Ring Hexamer [cytosol] (Homo sapiens)
Other forms of this molecule
EXOSC4 [nucleoplasm]
Inferred To
exosc4 [cytosol]
(Xenopus tropicalis)
ski6 [cytosol]
(Schizosaccharomyces pombe)
SKI6 [cytosol]
(Saccharomyces cerevisiae)
Exosc4 [cytosol]
(Mus musculus)
Exosc4 [cytosol]
(Rattus norvegicus)
EXOSC4 [cytosol]
(Bos taurus)
EXOSC4 [cytosol]
(Canis familiaris)
EXOSC4 [cytosol]
(Dictyostelium discoideum)
EXOSC4 [cytosol]
(Sus scrofa)
Ski6 [cytosol]
(Drosophila melanogaster)
exos-4.1 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of EXOSC4 [cytosol]
(Gallus gallus)
Cross References
RefSeq
NP_061910.1
OpenTargets
ENSG00000178896
HPA
ENSG00000178896-EXOSC4
GeneCards
Q9NPD3
Ensembl
ENSG00000178896
,
ENSP00000315476
,
ENST00000316052
PRO
Q9NPD3
Pharos - Targets
Q9NPD3
PDB
6D6R
,
6H25
,
2NN6
,
6D6Q
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q01780 EXOSC10
1
EXOSC10 [nucleoplasm]
(R-HSA-6791547)
0.798
5
UniProt:Q9NQT4 EXOSC5
2
EXOSC5 [cytosol]
(R-HSA-429889)
EXOSC5 [nucleoplasm]
(R-HSA-6791550)
0.643
4
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:Q99547 MPHOSPH6
1
MPHOSPH6 [nucleoplasm]
(R-HSA-6791553)
0.527
2
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.527
3
UniProt:Q9Y2L1 DIS3
2
DIS3 [nucleoplasm]
(R-HSA-6791517)
DIS3 [cytosol]
(R-HSA-429935)
0.462
2
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