Reactome | DCP2 [cytosol]

DCP2 [cytosol]

Stable Identifier

R-HSA-429937

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

mRNA-decapping enzyme 2, DCP2_HUMAN

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Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Unfolded Protein Response (UPR) (Homo sapiens)
    - PERK regulates gene expression (Homo sapiens)
      - ATF4 activates genes in response to endoplasmic reticulum stress (Homo sapiens)
        
        Expression of IL-8 (Homo sapiens)
        
        KSRP:mRNA Degradation Complex [cytosol] (Homo sapiens)
        
        DCP2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8IU60 DCP2

Gene Names

DCP2, NUDT20

Chain

chain:1-420

Reference Genes

BioGPS Gene:167227 DCP2

COSMIC (genes):DCP2 DCP2

CTD Gene:167227 DCP2

dbSNP Gene:167227 DCP2

ENSEMBL:ENSG00000172795 DCP2

ENSEMBL_homo_sapiens_GENE:ENSG00000172795.17 DCP2

HGNC:24452 DCP2

KEGG Gene (Homo sapiens):167227 DCP2

Monarch:167227 DCP2

NCBI Gene:167227 DCP2

OMIM:609844 DCP2

UCSC:Q8IU60 DCP2

Reference Transcript

Other Identifiers

11719738_at

11719739_s_at

11719740_a_at

11719741_a_at

11758428_s_at

167227

16988062

212919_PM_at

212919_at

235258_PM_at

235258_at

238779_PM_at

238779_at

2824355

2824356

2824357

2824358

2824359

2824368

2824372

2824373

2824374

2824377

2824379

2824380

2824381

2824382

2824384

2824386

2824387

2824388

2824389

2824390

2824391

2824393

2824394

2824396

2824398

2824400

2824401

34191_at

48327_at

54487_at

8107356

85532_at

A_14_P118466

A_23_P256868

A_24_P886040

GO:0000184

GO:0000290

GO:0000932

GO:0003723

GO:0003824

GO:0004534

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006402

GO:0016071

GO:0016442

GO:0016787

GO:0016896

GO:0030054

GO:0030145

GO:0032200

GO:0032211

GO:0036464

GO:0043226

GO:0043488

GO:0043928

GO:0046872

GO:0070034

GO:0071044

GO:0140098

GO:0140933

GO:1904872

HMNXSV003001576

HMNXSV003012823

Hs.21056.0.S1_3p_at

Hs.62632.0.A1_3p_at

Hs.89034.0.A1_3p_at

ILMN_1669905

PH_hs_0030283

TC05000535.hg

TC05002568.hg

Participates

as an input of

as a component of

Inferred To

DCP2 [cytosol] (Bos taurus)

DCP2 [cytosol] (Caenorhabditis elegans)

DCP2 [cytosol] (Canis familiaris)

DCP2 [cytosol] (Drosophila melanogaster)

DCP2 [cytosol] (Gallus gallus)

DCP2 [cytosol] (Mus musculus)

DCP2 [cytosol] (Plasmodium falciparum)

DCP2 [cytosol] (Saccharomyces cerevisiae)

DCP2 [cytosol] (Sus scrofa)

dcp2 [cytosol] (Dictyostelium discoideum)

dcp2 [cytosol] (Xenopus tropicalis)

Dcp2 [cytosol] (Rattus norvegicus)

zgc:55938 [cytosol] (Danio rerio)

Cross References

RefSeq

NP_689837.2, NP_001229306.1

OpenTargets

ENSG00000172795

IntEnz

3.6.1.62

GeneCards

Q8IU60

HPA

ENSG00000172795-DCP2

Ensembl

ENSG00000172795, ENSP00000373715, ENST00000515408, ENST00000389063, ENSP00000425770

PRO

Q8IU60

Pharos - Targets

Q8IU60

HMDB Protein

HMDBP08710

PDB

5QOW, 5QOS, 5QP1, 5QP9, 5QP5, 5QOK, 5QPA, 5QOR, 5QOZ, 5QP2, 5QP6, 5QOV, 5QPB, 5QOJ, 5QOQ, 5QOY, 5QOI, 5QOU, 5QP7, 5QOP, 5QOH, 5QP3, 5MP0, 5QPC, 5QOT, 5QP8, 5QOX, 5QON, 5QOO, 5QP0, 5QP4, 5QOL, 5QOM

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NPI6 DCP1A	1	DCP1A [cytosol] (R-HSA-430043)	0.937	16
UniProt:Q6P2E9 EDC4	1	EDC4 [cytosol] (R-HSA-429963)	0.76	8
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.641	3
UniProt:Q3UJB9	1	Edc4 [cytosol] (R-MMU-429963)	0.564	2
UniProt:Q8IZD4 DCP1B	1	DCP1B [cytosol] (R-HSA-429834)	0.547	3