Reactome | Passive I- efflux mediated by SLC5A8

Passive I- efflux mediated by SLC5A8

Stable Identifier

R-HSA-429767

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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SLC5A8 encodes the apical iodide transporter, AIT (also known as SMCT1). As well as functioning as a Na+-dependent monocarboxylate co-transporter, AIT mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane (Rodriguez AM et al, 2002). AIT, together with NIS (see previous reaction), mediates iodide transfer from blood to the colloid lumen of thyrocytes.

Literature References

PubMed ID	Title	Journal	Year
12107270	Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes Rodriguez, AM, Perron, B, Lacroix, L, Caillou, B, Leblanc, G, Schlumberger, M, Bidart, JM, Pourcher, T	J Clin Endocrinol Metab	2002