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Activation of RAC1
Stable Identifier
R-HSA-428540
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Activation of RAC1 (Homo sapiens)
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A low level of RAC1 activity is essential to maintain axon outgrowth. ROBO activation recruits SOS, a dual specificity GEF, to the plasma membrane via Dock homolog NCK (NCK1 or NCK2) to activate RAC1 during midline repulsion.
Participants
Events
NCK binds ROBO1:SLIT2
(Homo sapiens)
Recruitment of PAK to NCK
(Homo sapiens)
Recruitment of SOS to plasma membrane
(Homo sapiens)
Activation of RAC1 by SOS
(Homo sapiens)
Participates
as an event of
Signaling by ROBO receptors (Homo sapiens)
Event Information
Go Biological Process
Rac protein signal transduction (0016601)
Authored
Garapati, P V (2008-09-05)
Reviewed
Jaworski, A (2017-07-31)
Kidd, T (2009-08-18)
Created
Garapati, P V (2009-07-06)
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