Inactivation of RAC1

Stable Identifier
R-HSA-428522
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Inactivation of RAC1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Vilse and its human homolog ARHGAP39 bind directly to the intracellular domains of the corresponding ROBO receptors and promote the hydrolysis of GTP bound to RAC1 (Lundstrom et al. 2004, Hu et al. 2005).
Participants
Input
Output
Participates
as an event of
Catalyst Activity

GTPase activator activity of ROBO1:SLIT2:ARHGAP39 [plasma membrane]

Physical Entity
ROBO1:SLIT2:ARHGAP39 [plasma membrane] (Homo sapiens)
Activity
GTPase activator activity (GO:0005096)
Inferred From
Inactivation of Rac1 (Drosophila melanogaster)
Authored
Garapati, P V  (2008-09-05)
Reviewed
Jaworski, A  (2017-07-31)
Kidd, T  (2009-08-18)
Created
Garapati, P V  (2009-07-06)
Cite Us!