Reactome | DAGLB [plasma membrane]

DAGLB [plasma membrane]

Stable Identifier

R-HSA-426020

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Diacylglycerol lipase beta, Sn1-specific diacylglycerol lipase beta, DGLB_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Effects of PIP2 hydrolysis (Homo sapiens)
        
        Arachidonate production from DAG (Homo sapiens)
        
        DAG is metabolized by DAGL to 2-AG (Homo sapiens)
        
        Diacylglycerol lipase [plasma membrane] (Homo sapiens)
        
        DAGLB [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8NCG7 DAGLB

Gene Names

DAGLB

Chain

chain:1-672

Reference Genes

BioGPS Gene:221955 DAGLB

COSMIC (genes):DAGLB DAGLB

CTD Gene:221955 DAGLB

dbSNP Gene:221955 DAGLB

ENSEMBL:ENSG00000164535 DAGLB

ENSEMBL_homo_sapiens_GENE:ENSG00000164535.15 DAGLB

HGNC:28923 DAGLB

KEGG Gene (Homo sapiens):221955 DAGLB

Monarch:221955 DAGLB

NCBI Gene:221955 DAGLB

OMIM:614016 DAGLB

UCSC:Q8NCG7 DAGLB

Reference Transcript

Other Identifiers

11720933_s_at

11720934_a_at

11741500_a_at

17055013

221955

225828_PM_at

225828_at

225832_3p_s_at

225832_PM_s_at

225832_s_at

225833_PM_at

225833_at

226640_PM_at

226640_at

3037343

3037345

3037346

3037347

3037349

3037350

3037354

3037356

3037358

3037366

3037368

3037371

3037372

3037373

3037374

3037375

3037376

3037380

3037381

3037382

3037383

3037384

44078_at

50944_g_at

59960_at

8138091

A_23_P8539

GE79747

GO:0001516

GO:0003824

GO:0004806

GO:0005515

GO:0005634

GO:0005654

GO:0005764

GO:0005765

GO:0005773

GO:0005886

GO:0006629

GO:0006640

GO:0006690

GO:0006954

GO:0007405

GO:0010898

GO:0016020

GO:0016042

GO:0016298

GO:0016787

GO:0019369

GO:0022008

GO:0030154

GO:0043226

GO:0046340

GO:0046872

GO:0047372

GO:0048856

GO:0050727

GO:1901696

HMNXSV003008476

Hs.131899.0.A1_3p_at

Hs.131899.1.A1_3p_at

Hs.131899.1.A2_3p_a_at

Hs.131899.1.A2_3p_at

ILMN_1658885

PH_hs_0007851

TC07003349.hg

Participates

as a member of

Diacylglycerol lipase [plasma membrane] (Homo sapiens)

Inferred To

DAGLB [plasma membrane] (Bos taurus)

DAGLB [plasma membrane] (Canis familiaris)

DAGLB [plasma membrane] (Dictyostelium discoideum)

DAGLB [plasma membrane] (Gallus gallus)

DAGLB [plasma membrane] (Sus scrofa)

daglb [plasma membrane] (Xenopus tropicalis)

Daglb [plasma membrane] (Mus musculus)

Daglb [plasma membrane] (Rattus norvegicus)

Homologues of DAGLB [plasma membrane] (Dictyostelium discoideum)

dagl-2 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001136408.1, NP_631918.3

ZINC - World Drugs

DGLB_HUMAN

Guide to Pharmacology - Targets

1397

OpenTargets

ENSG00000164535

ZINC - FDA approved

DGLB_HUMAN

ZINC - Substances

DGLB_HUMAN

ZINC target

Q8NCG7

PRO

Q8NCG7

IntEnz

3.1.1.116, 3.1.1.3

HPA

ENSG00000164535-DAGLB

GeneCards

Q8NCG7

Ensembl

ENSP00000297056, ENSG00000164535, ENSP00000391171, ENST00000425398, ENST00000297056

Pharos - Targets

Q8NCG7

ZINC - Predictions - Purchasable

DGLB_HUMAN

HMDB Protein

HMDBP07283

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.462	2