Reactome | PTH1R [plasma membrane]

PTH1R [plasma membrane]

Stable Identifier

R-HSA-420479

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Parathyroid hormone/parathyroid hormone-related peptide receptor, PTH1R_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R [plasma membrane] (Homo sapiens)
        
        PTH1R [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R [plasma membrane] (Homo sapiens)
        
        PTH1R [plasma membrane] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R [plasma membrane] (Homo sapiens)
        
        PTH1R [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R [plasma membrane] (Homo sapiens)
        
        PTH1R [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R [plasma membrane] (Homo sapiens)
        
        PTH1R [plasma membrane] (Homo sapiens)
        
        GPCRs that activate Gs [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R [plasma membrane] (Homo sapiens)
        
        PTH1R [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class B/2 (Secretin family receptors) (Homo sapiens)
      - Parathyroid hormone receptor can bind parathyroid hormone (Homo sapiens)
        
        PTH1R,PTH2R [plasma membrane] (Homo sapiens)
        
        PTH1R [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R [plasma membrane] (Homo sapiens)
        
        PTH1R [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q03431 PTH1R

Gene Names

PTH1R, PTHR, PTHR1

Chain

signal peptide:1-26, chain:27-593

Reference Genes

BioGPS Gene:5745 PTH1R

COSMIC (genes):PTH1R PTH1R

CTD Gene:5745 PTH1R

dbSNP Gene:5745 PTH1R

ENSEMBL:ENSG00000160801 PTH1R

ENSEMBL_homo_sapiens_GENE:ENSG00000160801.14 PTH1R

HGNC:9608 PTH1R

KEGG Gene (Homo sapiens):5745 PTH1R

Monarch:5745 PTH1R

NCBI Gene:5745 PTH1R

OMIM:168468 PTH1R

UCSC:Q03431 PTH1R

Reference Transcript

Other Identifiers

11725200_a_at

16940239

205911_PM_at

205911_at

2621033

2621034

2621037

2621038

2621039

2621047

2621052

2621053

2621054

2621055

2621058

2621060

2621061

2621063

2621064

2621065

2621067

2621070

2621073

2621075

2621078

2621079

532_at

533_g_at

5745

8079433

A_23_P167030

GE58971

GO:0001501

GO:0001503

GO:0001701

GO:0002062

GO:0002076

GO:0004888

GO:0004930

GO:0004991

GO:0005515

GO:0005634

GO:0005737

GO:0005886

GO:0005975

GO:0006874

GO:0007165

GO:0007166

GO:0007186

GO:0007187

GO:0007188

GO:0007189

GO:0007200

GO:0008283

GO:0008284

GO:0008285

GO:0008528

GO:0016020

GO:0016323

GO:0016324

GO:0017046

GO:0023052

GO:0030154

GO:0030282

GO:0042803

GO:0043226

GO:0043235

GO:0043621

GO:0045453

GO:0048469

GO:0048856

GO:0055065

GO:0060089

GO:0060732

HMNXSV003000208

ILMN_1795166

PH_hs_0000130

PH_hs_0030862

TC03000262.hg

U17418_at

g4506270_3p_at

Participates

as a member of

PTH1R,PTH2R [plasma membrane] (Homo sapiens)

Inferred To

pth1ra [plasma membrane] (Danio rerio)

Pth1r [plasma membrane] (Mus musculus)

Pth1r [plasma membrane] (Rattus norvegicus)

pth1r [plasma membrane] (Xenopus tropicalis)

PTH1R [plasma membrane] (Bos taurus)

PTH1R [plasma membrane] (Canis familiaris)

PTH1R [plasma membrane] (Gallus gallus)

PTH1R [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_000307.1, NP_001171673.1, XP_016862422.1

Guide to Pharmacology - Targets

331

OpenTargets

ENSG00000160801

ZINC - Substances

PTH1R_HUMAN

ZINC target

Q03431

PRO

Q03431

PDB

7UZO, 8FLR, 8HAF, 3H3G, 7VVJ, 7UZP, 8FLS, 8D52, 8FLU, 8JR9, 8HAO, 8FLT, 6NBF, 7VVL, 7VVK, 8GW8, 6NBH, 1BL1, 3C4M, 6NBI, 4Z8J, 7Y35, 7VVM, 8HA0, 7Y36, 7VVN, 3L2J, 8D51, 5EMB, 8FLQ, 7VVO

GeneCards

Q03431

HPA

ENSG00000160801-PTH1R

Ensembl

ENST00000418619, ENSP00000402723, ENST00000313049, ENST00000430002, ENST00000449590, ENSP00000411424, ENSG00000160801, ENSP00000321999, ENSP00000413774

Pharos - Targets

Q03431

Orphanet

15169

ZINC - Predictions - Purchasable

PTH1R_HUMAN

HMDB Protein

HMDBP07958

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.505	4