Reactome | GRM2 [plasma membrane]

GRM2 [plasma membrane]

Stable Identifier

R-HSA-420468

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Metabotropic glutamate receptor 2, GRM2_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM2 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM2 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM2 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
      - Metabotropic glutamate receptors bind glutamate (Homo sapiens)
        
        GRM1-8 [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM2 [plasma membrane] (Homo sapiens)
        
        GRM1-8:L-Glu [plasma membrane] (Homo sapiens)
        
        GRM1-8 [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14416 GRM2

Gene Names

GRM2, GPRC1B, MGLUR2

Chain

signal peptide:1-18, chain:19-872

Reference Genes

BioGPS Gene:2912 GRM2

COSMIC (genes):GRM2 GRM2

CTD Gene:2912 GRM2

dbSNP Gene:2912 GRM2

ENSEMBL:ENSG00000164082 GRM2

ENSEMBL_homo_sapiens_GENE:ENSG00000164082.15 GRM2

HGNC:4594 GRM2

KEGG Gene (Homo sapiens):2912 GRM2

Monarch:2912 GRM2

NCBI Gene:2912 GRM2

OMIM:604099 GRM2

UCSC:Q14416 GRM2

Reference Transcript

Other Identifiers

11729841_a_at

11750449_a_at

16941230

208465_PM_at

208465_at

241802_PM_x_at

241802_x_at

2623309

2623311

2623312

2623317

2623318

2623319

2623320

2912

32498_at

58160_at

8080128

A_23_P332178

A_33_P3358943

GE511294

GO:0001641

GO:0004930

GO:0005246

GO:0005515

GO:0005886

GO:0007165

GO:0007186

GO:0007194

GO:0007196

GO:0007215

GO:0007216

GO:0007268

GO:0008066

GO:0010467

GO:0014047

GO:0014048

GO:0014059

GO:0016020

GO:0023052

GO:0030424

GO:0030425

GO:0035095

GO:0042220

GO:0042734

GO:0042995

GO:0043005

GO:0045202

GO:0051897

GO:0051966

GO:0060089

GO:0060292

GO:0090461

GO:0097110

GO:0097449

GO:0098772

GO:0098978

GO:0099171

GO:2001023

HMNXSV003030743

HMNXSV003033713

Hs.106356.0.A1_3p_at

ILMN_1693604

PH_hs_0006763

TC03000322.hg

g4504136_3p_at

Participates

as a member of

GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)

Inferred To

grm7 [plasma membrane] (Danio rerio)

GRM2 [plasma membrane] (Bos taurus)

GRM2 [plasma membrane] (Caenorhabditis elegans)

GRM2 [plasma membrane] (Canis familiaris)

GRM2 [plasma membrane] (Drosophila melanogaster)

GRM2 [plasma membrane] (Gallus gallus)

GRM2 [plasma membrane] (Mus musculus)

GRM2 [plasma membrane] (Rattus norvegicus)

GRM2 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_000830.2, XP_016861760.1

ZINC - World Drugs

GRM2_HUMAN

Guide to Pharmacology - Targets

290

OpenTargets

ENSG00000164082

ZINC - FDA approved

GRM2_HUMAN

ZINC - Substances

GRM2_HUMAN

ZINC target

Q14416

ZINC - Biogenic

GRM2_HUMAN

PRO

Q14416

PDB

4XAQ, 8JCU, 7EPB, 8JD3, 8JD2, 5KZQ, 7EPA, 7E9G, 5KZN, 8JD1, 7MTR, 5CNJ, 8JCZ, 7MTS, 8JD0, 5CNI, 8JCY, 8JCX, 7MTQ, 8JCW, 8JD5, 4XAS, 8JCV, 8JD4, 7EPD

ZINC - Investigational

GRM2_HUMAN

ZINC - Metabolites

GRM2_HUMAN

HPA

ENSG00000164082-GRM2

GeneCards

Q14416

Ensembl

ENSG00000164082, ENSP00000378492, ENST00000395052

Pharos - Targets

Q14416

ZINC - Predictions - Purchasable

GRM2_HUMAN

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.556	3
UniProt:Q9H2H9 SLC38A1	1	SLC38A1 [plasma membrane] (R-HSA-212663)	0.556	3
UniProt:Q8IWU4 SLC30A8	2	SLC30A8 [Golgi membrane] (R-HSA-9817561) SLC30A8 [secretory granule membrane] (R-HSA-437106)	0.556	3
UniProt:P27487 DPP4	2	DPP4(39-766) [extracellular region] (R-HSA-400517) DPP4(1-766) [plasma membrane] (R-HSA-400527)	0.524	2
UniProt:Q9BYF1 ACE2	5	ACE2(18-805) [plasma membrane] (R-HSA-2022344) ACE2 [endoplasmic reticulum lumen] (R-HSA-9683474) glycosylated-ACE2 [endocytic vesicle membrane] (R-HSA-9686721) ACE2 [endocytic vesicle membrane] (R-HSA-9698958) glycosylated-ACE2 [plasma membrane] (R-HSA-9683480)	0.524	2
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9697006) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) fully glycosylated Spike [virion membrane] (R-COV-9698327) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791)	0.524	4