Reactome | PTH [extracellular region]

PTH [extracellular region]

Stable Identifier

R-HSA-420445

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Parathyroid hormone, PTHY_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
        
        PTH [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
        
        PTH [extracellular region] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
        
        PTH [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
        
        PTH [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
        
        PTH [extracellular region] (Homo sapiens)
        
        Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
        
        PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
        
        PTH [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class B/2 (Secretin family receptors) (Homo sapiens)
      - Parathyroid hormone receptor can bind parathyroid hormone (Homo sapiens)
        
        PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
        
        PTH [extracellular region] (Homo sapiens)
        
        PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)
        
        PTH [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01270 PTH

Gene Names

PTH

Chain

signal peptide:1-25, propeptide:26-31, chain:32-115

Reference Genes

BioGPS Gene:5741 PTH

COSMIC (genes):PTH PTH

CTD Gene:5741 PTH

dbSNP Gene:5741 PTH

ENSEMBL:ENSG00000152266 PTH

ENSEMBL_homo_sapiens_GENE:ENSG00000152266.7 PTH

HGNC:9606 PTH

KEGG Gene (Homo sapiens):5741 PTH

Monarch:5741 PTH

NCBI Gene:5741 PTH

OMIM:168450 PTH

UCSC:P01270 PTH

Reference Transcript

RefSeq:NM_000315.3 PTH

Other Identifiers

11719358_at

16735970

206977_PM_at

206977_at

3363687

3363688

3363689

3363690

3363692

3363694

34399_at

5741

708_at

7946687

A_23_P24835

GE532902

GO:0001501

GO:0005179

GO:0005515

GO:0005576

GO:0005615

GO:0005975

GO:0006091

GO:0006351

GO:0006355

GO:0006366

GO:0006874

GO:0007165

GO:0007186

GO:0007189

GO:0007202

GO:0007266

GO:0007267

GO:0008628

GO:0009059

GO:0009410

GO:0009967

GO:0010288

GO:0010468

GO:0010628

GO:0010629

GO:0010960

GO:0012501

GO:0023052

GO:0030154

GO:0030282

GO:0030501

GO:0031667

GO:0031856

GO:0031857

GO:0032331

GO:0033280

GO:0045453

GO:0045471

GO:0045725

GO:0045778

GO:0045944

GO:0046058

GO:0046326

GO:0046686

GO:0048018

GO:0048856

GO:0048873

GO:0051428

GO:0055062

GO:0055065

GO:0055074

GO:0055085

GO:0055086

GO:0060732

GO:0071107

GO:0071774

GO:0071864

GO:0071866

GO:0090290

GO:0098772

GO:1900158

GO:1901135

HMNXSV003043927

ILMN_1781669

ILMN_2202048

J00301_at

PH_hs_0002931

TC11001435.hg

g4506266_3p_at

Participates

as a member of

PTH1R,PTH2R ligands [extracellular region] (Homo sapiens)

Inferred To

Pth [extracellular region] (Mus musculus)

Pth [extracellular region] (Rattus norvegicus)

pth1 [extracellular region] (Danio rerio)

PTH [extracellular region] (Bos taurus)

PTH [extracellular region] (Canis familiaris)

PTH [extracellular region] (Gallus gallus)

PTH [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_000306.1

OpenTargets

ENSG00000152266

GeneCards

P01270

HPA

ENSG00000152266-PTH

Ensembl

ENST00000282091, ENSP00000433208, ENSP00000282091, ENST00000529816, ENSG00000152266

PRO

P01270

Pharos - Targets

P01270

Orphanet

15168

HMDB Protein

HMDBP02068

PDB

1ZWE, 7VVL, 1HPY, 2L1X, 8FLQ, 1ZWF, 1ZWA, 8HAO, 1FVY, 7Y36, 1HPH, 7VVM, 3C4M, 1ZWB, 1BWX, 8HA0, 1ZWD, 1HTH, 7VVN, 1ZWG, 7VVK, 7VVO, 1ET1