Reactome | VIP receptors bind VIP

VIP receptors bind VIP

Stable Identifier

R-HSA-420233

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Vasoactive intestinal peptide (VIP) (Tsukada T et al, 1985) belongs to the glucagon hormone family and is expressed in many parts of the human body. VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial muscle contraction and increases glycogenolysis. It also relaxes the smooth muscle of trachea, stomach and gall bladder. The effects of VIP are mediated by the VIP receptors of which there are two, 1 and 2 (Sreedharan SP et al, 1993 and Svodoba M et al, 1994 respectively). The actions of the receptor are mediated by coupling with the G protein alpha s subunit, which stimulates adenylyl cyclase which increases intracellular cAMP levels (Sreedharan SP et al, 1993).

Literature References

PubMed ID	Title	Journal	Year
3899557	Structure of the human vasoactive intestinal polypeptide gene Tsukada, T, Goodman, RH, Montminy, MR, Horovitch, SJ, Mandel, G	DNA	1985
7811244	Molecular cloning and functional characterization of a human VIP receptor from SUP-T1 lymphoblasts Robberecht, P, Svoboda, M, De Neef, P, Tastenoy, M, Waelbroeck, M, Goossens, JF, Van Rampelbergh, J	Biochem Biophys Res Commun	1994
8390245	Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor Sreedharan, SP, Goetzl, EJ, Patel, DR, Huang, JX	Biochem Biophys Res Commun	1993