The PACAP receptor binds PACAP

Stable Identifier
R-HSA-420131
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The pituitary adenylate cyclase-activating peptide (PACAP) (Ohkubo S et al, 1992) is a peptide hormone similar to vasoactive intestinal peptide (VIP). PACAP functions as a hypophysiotropic hormone, neurotransmitter and neuromodulator. Three active peptides are cleaved from the precursor protein; PACAP-related peptide, PACAP-27 and PACAP-38. The effects of the PACAP peptides are mediated by the PACAP receptor (Ogi K et al, 1993). This receptor is predominantly expressed in the CNS. The activity of the receptor is mediated by coupling with the G protein alpha s subunit, which stimulates adenylyl cyclase which increases intracellular cAMP levels (Ogi K et al, 1993).

Literature References
PubMed ID Title Journal Year
1739432 Primary structure and characterization of the precursor to human pituitary adenylate cyclase activating polypeptide

Ohkubo, S, Kimura, C, Ogi, K, Okazaki, K, Hosoya, M, Onda, H, Miyata, A, Arimura, A, Fujino, M

DNA Cell Biol 1992
7902709 Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor

Ogi, K, Miyamoto, Y, Masuda, Y, Habata, Y, Hosoya, M, Ohtaki, T, Masuo, Y, Onda, H, Fujino, M

Biochem Biophys Res Commun 1993
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