Glucagon-like receptor 2 binds GLP2

Stable Identifier
R-HSA-420123
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Glucagon-like peptide 2 (GLP-2) (Drucker DJ 1999) is a 33-aa proglucagon-derived peptide produced by intestinal enteroendocrine cells. GLP-2 stimulates intestinal growth. The effects of GLP-2 are mediated by the GLP2 receptor (Munroe DG et al, 1999), which can couple with G protein alpha s subunit that activates adenylyl cyclase (Koehler JA et al, 2005).
Literature References
PubMed ID Title Journal Year
9990065 Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2

Munroe, DG, Sumner-Smith, M, Kooshesh, F, Gupta, AK, Drucker, DJ, Wang, H, Rizkalla, G, Kamboj, RK, Demchyshyn, L, Crivici, A, McCallum, K, Vyas, TB, Yang, ZJ, Chen, H

Proc Natl Acad Sci U S A 1999
15471943 The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways

Koehler, JA, Drucker, DJ, Yusta, B

Mol Endocrinol 2005
10322410 Glucagon-like Peptide 2

Drucker, DJ

Trends Endocrinol Metab 1999
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