Dimerization of LIMK1 by Hsp90

Stable Identifier
R-HSA-419645
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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After phosphorylation on Thr 508, LIMK undergoes homodimerization. Homodimer formation is promoted by the binding of heat shock protein 90 (Hsp90) to a short sequence in the kinase domain of LIMKs. LIMKs are further phosphorylated after homodimer formation and transphosphorylation of the kinase domain.

Literature References
PubMed ID Title Journal Year
17188549 Lim kinases, regulators of actin dynamics

Bernard, O

Int J Biochem Cell Biol 2007
16641196 Hsp90 increases LIM kinase activity by promoting its homo-dimerization

Li, R, Soosairajah, J, Harari, D, Citri, A, Price, J, Ng, HL, Morton, CJ, Parker, MW, Yarden, Y, Bernard, O

FASEB J 2006
Participants
Participant Of
Orthologous Events
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Created