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FANCB [nucleoplasm]
Stable Identifier
R-HSA-419528
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Fanconi anemia group B protein, FANCB_HUMAN
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Fanconi Anemia Pathway (Homo sapiens)
ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
DNA nucleases bind monoubiquitinated ID2 complex (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
DNA nucleases unhook the interstrand crosslink (ICL) (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
FA core complex assembles at DNA interstrand crosslinks (ICLs) (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
FANCD2 deubiquitination by USP1:WDR48 (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
Monoubiquitination of FANCD2:FANCI (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
POLN binds ICL-DNA (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
The complex of ATR and ATRIP is recruited to ICL-DNA (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
Translesion synthesis across unhooked ICL by POLN (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NB91 FANCB
Gene Names
FANCB
Chain
initiator methionine:, chain:2-859
Reference Genes
BioGPS Gene:2187 FANCB
COSMIC (genes):FANCB FANCB
CTD Gene:2187 FANCB
dbSNP Gene:2187 FANCB
ENSEMBL:ENSG00000181544 FANCB
ENSEMBL_homo_sapiens_GENE:ENSG00000181544.16 FANCB
HGNC:3583 FANCB
KEGG Gene (Homo sapiens):2187 FANCB
Monarch:2187 FANCB
NCBI Gene:2187 FANCB
OMIM:300515 FANCB
UCSC:Q8NB91 FANCB
Reference Transcript
RefSeq:NM_001324162.1 FANCB
RefSeq:NM_152633.3 FANCB
RefSeq:XM_017029355.1 FANCB
RefSeq:NM_001018113.2 FANCB
Other Identifiers
11735300_a_at
1553244_PM_at
1553244_at
1557217_PM_a_at
1557217_a_at
1557218_PM_s_at
1557218_s_at
17109211
2187
4000386
4000387
4000388
4000389
4000390
4000391
4000392
4000393
4000395
4000397
4000398
4000403
4000404
4000405
4000406
4000408
8171381
A_23_P356021
GE600362
GO:0000785
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006281
GO:0006310
GO:0006513
GO:0006974
GO:0036211
GO:0036297
GO:0043226
GO:0043240
GO:1905168
GO:1990414
GO:2000042
HMNXSV003007108
Hs2.277254.1.S1_3p_at
Hs2.277254.2.S1_3p_s_at
ILMN_1698252
ILMN_1726756
PH_hs_0014239
TC0X000872.hg
Participates
as a component of
FA core complex [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
as an input of
FA core complex assembles at DNA interstrand crosslinks (ICLs) (Homo sapiens)
Other forms of this molecule
FANCB [cytosol]
Inferred To
fancb [nucleoplasm]
(Xenopus tropicalis)
FANCB [nucleoplasm]
(Bos taurus)
FANCB [nucleoplasm]
(Canis familiaris)
FANCB [nucleoplasm]
(Gallus gallus)
FANCB [nucleoplasm]
(Sus scrofa)
Fancb [nucleoplasm]
(Mus musculus)
Fancb [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_001018123.1
,
NP_001311091.1
,
XP_016884844.1
,
NP_689846.1
OpenTargets
ENSG00000181544
GeneCards
Q8NB91
HPA
ENSG00000181544-FANCB
Ensembl
ENST00000650831
,
ENST00000696357
,
ENST00000324138
,
ENSP00000512577
,
ENSP00000326819
,
ENST00000696356
,
ENSP00000498215
,
ENST00000696312
,
ENSP00000512550
,
ENSP00000512578
,
ENSG00000181544
PRO
Q8NB91
Pharos - Targets
Q8NB91
Orphanet
16021
PDB
7KZP
,
7KZT
,
7KZR
,
7KZV
,
7KZS
,
7KZQ
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q0VG06 FAAP100
2
FAAP100 [cytosol]
(R-HSA-420799)
FAAP100 [nucleoplasm]
(R-HSA-419545)
0.556
4
UniProt:Q8IYD8 FANCM
3
FANCM [nucleoplasm]
(R-HSA-419535)
p-S1045-FANCM [nucleoplasm]
(R-HSA-6788401)
FANCM [cytosol]
(R-HSA-420802)
0.527
2
UniProt:O15360 FANCA
2
FANCA [nucleoplasm]
(R-HSA-419541)
FANCA [cytosol]
(R-HSA-420796)
0.527
3
UniProt:Q15435 PP1R7
0.508
2
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