Reactome | MTNR1B [plasma membrane]

MTNR1B [plasma membrane]

Stable Identifier

R-HSA-419349

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Melatonin receptor type 1B, MTR1B_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Melatonin receptors:melatonin [plasma membrane] (Homo sapiens)
        
        Melatonin receptors [plasma membrane] (Homo sapiens)
        
        MTNR1B [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Melatonin receptors:melatonin [plasma membrane] (Homo sapiens)
        
        Melatonin receptors [plasma membrane] (Homo sapiens)
        
        MTNR1B [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Melatonin receptors:melatonin [plasma membrane] (Homo sapiens)
        
        Melatonin receptors [plasma membrane] (Homo sapiens)
        
        MTNR1B [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Melatonin receptors:melatonin [plasma membrane] (Homo sapiens)
        
        Melatonin receptors [plasma membrane] (Homo sapiens)
        
        MTNR1B [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Melatonin receptors:melatonin [plasma membrane] (Homo sapiens)
        
        Melatonin receptors [plasma membrane] (Homo sapiens)
        
        MTNR1B [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Melatonin receptors:melatonin [plasma membrane] (Homo sapiens)
        
        Melatonin receptors [plasma membrane] (Homo sapiens)
        
        MTNR1B [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Melatonin receptors can bind melatonin (Homo sapiens)
        
        Melatonin receptors [plasma membrane] (Homo sapiens)
        
        MTNR1B [plasma membrane] (Homo sapiens)
        
        Melatonin receptors:melatonin [plasma membrane] (Homo sapiens)
        
        Melatonin receptors [plasma membrane] (Homo sapiens)
        
        MTNR1B [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49286 MTNR1B

Gene Names

MTNR1B

Chain

chain:1-362

Reference Genes

BioGPS Gene:4544 MTNR1B

COSMIC (genes):MTNR1B MTNR1B

CTD Gene:4544 MTNR1B

dbSNP Gene:4544 MTNR1B

ENSEMBL:ENSG00000134640 MTNR1B

ENSEMBL_homo_sapiens_GENE:ENSG00000134640.3 MTNR1B

HGNC:7464 MTNR1B

KEGG Gene (Homo sapiens):4544 MTNR1B

Monarch:4544 MTNR1B

NCBI Gene:4544 MTNR1B

OMIM:600804 MTNR1B

UCSC:P49286 MTNR1B

Reference Transcript

Other Identifiers

11737379_at

16730021

208516_PM_at

208516_at

31405_at

3344614

3344615

3344616

3344617

3344627

3344628

3344629

3344630

3344631

3344632

4544

7943098

A_23_P127418

GO:0003013

GO:0004930

GO:0005515

GO:0005886

GO:0007165

GO:0007186

GO:0007187

GO:0007268

GO:0008502

GO:0010754

GO:0012501

GO:0016020

GO:0023052

GO:0042593

GO:0042753

GO:0043010

GO:0043524

GO:0045202

GO:0045906

GO:0046010

GO:0046676

GO:0048856

GO:0050796

GO:0050877

GO:0051481

GO:0051970

GO:0051971

GO:0060089

GO:0098908

HMNXSV003026247

ILMN_1811678

PH_hs_0022638

TC11000905.hg

TC11002828.hg

g5174594_3p_at

Participates

as a member of

Melatonin receptors [plasma membrane] (Homo sapiens)

Inferred To

MTNR1B [plasma membrane] (Bos taurus)

MTNR1B [plasma membrane] (Canis familiaris)

MTNR1B [plasma membrane] (Gallus gallus)

MTNR1B [plasma membrane] (Sus scrofa)

Tre1 [plasma membrane] (Drosophila melanogaster)

moody [plasma membrane] (Drosophila melanogaster)

Mtnr1b [plasma membrane] (Mus musculus)

Mtnr1b [plasma membrane] (Rattus norvegicus)

Homologues of MTNR1B [plasma membrane] (Drosophila melanogaster)

mtnr1bb [plasma membrane] (Danio rerio)

npr-25 [plasma membrane] (Caenorhabditis elegans)

EG:22E5.10 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_005950.1, XP_011541141.1

ZINC - World Drugs

MTR1B_HUMAN

Guide to Pharmacology - Targets

288

OpenTargets

ENSG00000134640

ZINC - FDA approved

MTR1B_HUMAN

ZINC - Substances

MTR1B_HUMAN

ZINC - Biogenic

MTR1B_HUMAN

ZINC target

P49286

PRO

P49286

PDB

6ME9, 6ME7, 7VH0, 6ME8, 6ME6

ZINC - Investigational

MTR1B_HUMAN

ZINC - Metabolites

MTR1B_HUMAN

HPA

ENSG00000134640-MTNR1B

GeneCards

P49286

Ensembl

ENSG00000134640, ENSP00000257068, ENST00000257068

Pharos - Targets

P49286

ZINC - Predictions - Purchasable

MTR1B_HUMAN

Orphanet

26876

HMDB Protein

HMDBP10873

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21333 FLNA	3	FLNA [extracellular region] (R-HSA-350712) p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [cytosol] (R-HSA-210019)	0.547	2
UniProt:Q15084 PDIA6	3	PDIA6 [endoplasmic reticulum membrane] (R-HSA-535530) p-PDIA6 [endoplasmic reticulum lumen] (R-HSA-8957031) PDIA6 [endoplasmic reticulum lumen] (R-HSA-3009049)	0.527	2
UniProt:P27824 CANX	2	CANX [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.527	2
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.527	2