Reactome | MYH10 [cytosol]

MYH10 [cytosol]

Stable Identifier

R-HSA-419174

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Myosin-10, MYH10_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPHA-mediated growth cone collapse (Homo sapiens)
        
        Activated ROCK phosphorylates MRLCs (Homo sapiens)
        
        Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)
        
        MYH10 [cytosol] (Homo sapiens)
        
        p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)
        
        MYH10 [cytosol] (Homo sapiens)
    - Semaphorin interactions (Homo sapiens)
      - Sema4D in semaphorin signaling (Homo sapiens)
        
        Sema4D induced cell migration and growth-cone collapse (Homo sapiens)
        
        Myosin regulatory light chain phosphorylation by ROCK (Homo sapiens)
        
        Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)
        
        MYH10 [cytosol] (Homo sapiens)
        
        p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)
        
        MYH10 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35580 MYH10

Gene Names

MYH10

Chain

chain:1-1976

Reference Genes

BioGPS Gene:4628 MYH10

COSMIC (genes):MYH10 MYH10

CTD Gene:4628 MYH10

dbSNP Gene:4628 MYH10

ENSEMBL:ENSG00000133026 MYH10

ENSEMBL_homo_sapiens_GENE:ENSG00000133026.14 MYH10

HGNC:7568 MYH10

KEGG Gene (Homo sapiens):4628 MYH10

Monarch:4628 MYH10

NCBI Gene:4628 MYH10

OMIM:160776 MYH10

UCSC:P35580 MYH10

Reference Transcript

Other Identifiers

11736044_a_at

11736045_a_at

11754984_s_at

16840982

212372_PM_at

212372_at

213067_PM_at

213067_at

32838_at

3744462

3744464

3744465

3744466

3744467

3744468

3744469

3744470

3744471

3744473

3744474

3744475

3744476

3744478

3744480

3744481

3744483

3744485

3744486

3744490

3744491

3744492

3744493

3744495

3744497

3744498

3744501

3744503

3744504

3744505

3744506

3744507

3744510

3744512

3744518

3744521

3744522

3744525

3744527

3744528

3744529

3744531

3744532

3744534

3744537

3744546

3744552

3744553

3744558

3744565

3744568

3744569

3744573

40900_at

4628

68976_at

68979_g_at

8012475

A_24_P256764

A_24_P34168

A_33_P3235004

GE58791

GO:0000146

GO:0000166

GO:0000278

GO:0000281

GO:0000910

GO:0001725

GO:0003723

GO:0003774

GO:0003779

GO:0005515

GO:0005516

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0005844

GO:0005856

GO:0005886

GO:0005938

GO:0007010

GO:0007155

GO:0008092

GO:0008360

GO:0016459

GO:0016460

GO:0030027

GO:0030048

GO:0030496

GO:0031032

GO:0032154

GO:0032982

GO:0035613

GO:0042641

GO:0042995

GO:0043226

GO:0043531

GO:0048027

GO:0048856

GO:0050714

GO:0051015

GO:0070062

GO:0097513

GO:0140657

HMNXSV003055640

Hs.182919.0.A1_3p_at

Hs.296842.0.S1_3p_at

ILMN_1815154

M69181_at

PH_hs_0023429

S67247_s_at

TC17001118.hg

TC17002479.hg

U34301_at

U34301_r_at

Participates

as a member of

Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)

Inferred To

ZIP1 [cytosol] (Saccharomyces cerevisiae)

MYH10 [cytosol] (Bos taurus)

MYH10 [cytosol] (Caenorhabditis elegans)

MYH10 [cytosol] (Dictyostelium discoideum)

MYH10 [cytosol] (Drosophila melanogaster)

MYH10 [cytosol] (Gallus gallus)

MYH10 [cytosol] (Mus musculus)

MYH10 [cytosol] (Rattus norvegicus)

MYH10 [cytosol] (Saccharomyces cerevisiae)

MYH10 [cytosol] (Schizosaccharomyces pombe)

Homologues of MYH10 [cytosol] (Saccharomyces cerevisiae)

Homologues of MYH10 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_005955.3, NP_001243024.1, XP_016880169.1, XP_016880171.1, XP_016880170.1, NP_001242941.1

OpenTargets

ENSG00000133026

HPA

ENSG00000133026-MYH10

GeneCards

P35580

Ensembl

ENSP00000508862, ENST00000269243, ENSG00000133026, ENST00000686654, ENSP00000509241, ENSP00000369315, ENSP00000509748, ENST00000687178, ENST00000379980, ENSP00000269243, ENSP00000353590, ENST00000693441, ENSP00000509091, ENST00000688902, ENST00000360416

PRO

P35580

Pharos - Targets

P35580

PDB

4PD3

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	21
UniProt:Q14164 IKBKE	5	monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535) IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) K63polyUb-K30,K401-IKBKE [cytosol] (R-HSA-9730436) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521)	0.589	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4