Recruitment and activation of N-WASP by Cdc42

Stable Identifier
R-HSA-418874
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The adaptor protein Nck-1 binds to DCC and recruits Rac-1, Cdc42 and their effectors PAK-1 and N-WASP to the activated receptor. Both Cdc42 and Nck-1 are activators of N-WASP. Cdc42 in its active GTP bound form binds to the CRIB domain of N-WASP and this interaction along with PIP2 results in the activation of N-WASP. Nck-1 activate N-WASP via binding of its SH3 domain to the proline rich domain of N-WASP. Nck-1 also possess an SH2 domain that associates directly with activated tyrosine kinase receptors which can phosphorylate N-WASP.

Literature References
PubMed ID Title Journal Year
15040784 Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex

Millard, TH, Sharp, SJ, Machesky, LM

Biochem J 2004
10995436 Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate

Rohatgi, R, Ho, HY, Kirschner, MW

J Cell Biol 2000
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