Activation of Cdc42

Stable Identifier
R-HSA-418850
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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RhoGEF complexed with Netrin-1-DCC induces guanine nucleotide exchange by Cdc42, activating it. Activated Cdc42 activates N-WASP, which promotes the nucleation of F-actin via the Arp2/3 complex. Netrin-1, via DCC, influences cellular motility by regulating actin-based membrane extension through the activation of Cdc42.

Literature References
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Participant Of
Catalyst Activity
Catalyst Activity
Title
Rho guanyl-nucleotide exchange factor activity of NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Created