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P2RY4 [plasma membrane]
Stable Identifier
R-HSA-417861
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
P2Y purinoceptor 4, P2RY4_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
P2RY4:UTP [plasma membrane] (Homo sapiens)
P2RY4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
P2RY4:UTP [plasma membrane] (Homo sapiens)
P2RY4 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
P2RY4:UTP [plasma membrane] (Homo sapiens)
P2RY4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
P2RY4:UTP [plasma membrane] (Homo sapiens)
P2RY4 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
P2RY4:UTP [plasma membrane] (Homo sapiens)
P2RY4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
P2RY4:UTP [plasma membrane] (Homo sapiens)
P2RY4 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Nucleotide-like (purinergic) receptors (Homo sapiens)
P2Y receptors (Homo sapiens)
P2Y4 receptor can bind to UTP (Homo sapiens)
P2RY4 [plasma membrane] (Homo sapiens)
P2RY4:UTP [plasma membrane] (Homo sapiens)
P2RY4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51582 P2RY4
Gene Names
P2RY4, NRU
Chain
chain:1-365
Reference Genes
BioGPS Gene:5030 P2RY4
COSMIC (genes):P2RY4 P2RY4
CTD Gene:5030 P2RY4
dbSNP Gene:5030 P2RY4
ENSEMBL:ENSG00000186912 P2RY4
ENSEMBL_homo_sapiens_GENE:ENSG00000186912.7 P2RY4
HGNC:8542 P2RY4
KEGG Gene (Homo sapiens):5030 P2RY4
Monarch:5030 P2RY4
NCBI Gene:5030 P2RY4
OMIM:300038 P2RY4
UCSC:P51582 P2RY4
Reference Transcript
RefSeq:NM_002565.3 P2RY4
Other Identifiers
11734343_at
17111804
221466_PM_at
221466_at
4011619
4011621
4011622
4011623
4011624
5030
8173366
A_23_P114307
GE80679
GO:0004930
GO:0005515
GO:0005524
GO:0005886
GO:0007165
GO:0007186
GO:0007200
GO:0007204
GO:0016020
GO:0016192
GO:0016323
GO:0016324
GO:0023052
GO:0030321
GO:0035589
GO:0045028
GO:0045030
GO:0048787
GO:0055065
GO:0060089
GO:0071318
GO:0071380
GO:0098978
GO:0099509
GO:2000300
HMNXSV003031932
ILMN_1721630
PH_hs_0013170
TC0X001112.hg
U40223_at
g4505560_3p_at
Participates
as an input of
P2Y4 receptor can bind to UTP (Homo sapiens)
as a component of
P2RY4:UTP [plasma membrane] (Homo sapiens)
Inferred To
P2ry4 [plasma membrane]
(Mus musculus)
P2ry4 [plasma membrane]
(Rattus norvegicus)
P2RY4 [plasma membrane]
(Bos taurus)
P2RY4 [plasma membrane]
(Gallus gallus)
P2RY4 [plasma membrane]
(Sus scrofa)
p2ry4 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_002556.1
ZINC - World Drugs
P2RY4_HUMAN
Guide to Pharmacology - Targets
325
OpenTargets
ENSG00000186912
ZINC - Substances
P2RY4_HUMAN
ZINC target
P51582
ZINC - Biogenic
P2RY4_HUMAN
PRO
P51582
ZINC - Investigational
P2RY4_HUMAN
ZINC - Metabolites
P2RY4_HUMAN
GeneCards
P51582
HPA
ENSG00000186912-P2RY4
Ensembl
ENSP00000363643
,
ENST00000374519
,
ENSG00000186912
Pharos - Targets
P51582
ZINC - Predictions - Purchasable
P2RY4_HUMAN
HMDB Protein
HMDBP07860
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96CV9 OPTN
5
OPTN [recycling endosome membrane]
(R-HSA-8854141)
OPTN [Golgi membrane]
(R-HSA-2161111)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
OPTN [cytosol]
(R-HSA-9687907)
0.556
3
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