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SETDB1 [nucleoplasm]
Stable Identifier
R-HSA-417136
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone-lysine N-methyltransferase SETDB1, SETB1_HUMAN, ESET, KMT1E
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
ATF7IP binds SETDB1 (Homo sapiens)
ATF7IP:SETDB1 [nucleoplasm] (Homo sapiens)
SETDB1 [nucleoplasm] (Homo sapiens)
SETDB1 [nucleoplasm] (Homo sapiens)
SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Homo sapiens)
ATF7IP:SETDB1 [nucleoplasm] (Homo sapiens)
SETDB1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15047 SETDB1
Gene Names
SETDB1, ESET, KIAA0067, KMT1E
Chain
chain:1-1291
Reference Genes
BioGPS Gene:9869 SETDB1
COSMIC (genes):SETDB1 SETDB1
CTD Gene:9869 SETDB1
dbSNP Gene:9869 SETDB1
ENSEMBL:ENSG00000143379 SETDB1
HGNC:10761 SETDB1
KEGG Gene (Homo sapiens):9869 SETDB1
Monarch:9869 SETDB1
NCBI Gene:9869 SETDB1
OMIM:604396 SETDB1
UCSC:Q15047 SETDB1
Reference Transcript
RefSeq:XM_017002955.1 SETDB1
RefSeq:NM_001243491.1 SETDB1
RefSeq:NM_001145415.1 SETDB1
RefSeq:NM_012432.3 SETDB1
Other Identifiers
0002760672
00310+2.1.1.43
11719687_at
11757711_a_at
16670632
18142
203155_at
214197_s_at
2358521
2358522
2358523
2358527
2358528
2358530
2358531
2358533
2358534
2358537
2358541
2358542
2358543
2358544
2358545
2358546
2358548
2358549
2358552
2358553
2358554
2358555
2358557
2358559
2358560
2358562
2358563
2358565
2358567
2358568
2358569
34189_at
3DLM
4X3S
58484
5KCH
5KCO
5KE2
5KE3
5KH6
6AU2
6AU3
6BHD
6BHE
6BHG
6BHH
6BHI
6BPI
7905258
9869
A_14_P100717
A_23_P126393
A_23_P126398
A_33_P3252479
A_33_P3305399
AAH09362
AAH28671
AL590133
B0QZE6
BAA06689
BC009362
BC028671
CCDS44217
CCDS58026
CCDS972
CH471121
D31891
D31891_at
E9PAP1
E9PQM8
E9PRF4
E9PS59
EAW53506
ENSG00000143379
ENSP00000271640
ENSP00000357958
ENSP00000357965
ENST00000271640
ENST00000271640.9
ENST00000368962
ENST00000368962.6
ENST00000368969
ENST00000368969.8
EntrezGene:9869
EntrezGene:SETDB1
g6912651_3p_at
GE57172
GO:0003674
GO:0003677
GO:0003682
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0005886
GO:0006325
GO:0006464
GO:0007165
GO:0007265
GO:0008150
GO:0008168
GO:0008270
GO:0009058
GO:0016740
GO:0018024
GO:0032259
GO:0033273
GO:0034641
GO:0034968
GO:0043167
GO:0043226
GO:0043231
GO:0044403
GO:0045471
GO:0045869
GO:0046872
GO:0046974
GO:0051276
GO:0051567
GO:0090309
GO:1990841
HGNC:10761
HPA018142
HPA058484
Hs.20991.1.S1_3p_a_at
Hs.20991.1.S1_3p_at
ILMN_1718207
ILMN_1736080
IPR001214
IPR001739
IPR002999
IPR003616
IPR007728
IPR016177
IPR025796
IPR040880
IPR041291
IPR041292
MIM:604396
NM_001145415
NM_001243491
NM_001366417
NM_001366418
NM_012432
NP_001138887
NP_001230420
NP_001353346
NP_001353347
NP_036564
PF00856
PF01429
PF05033
PF18300
PF18358
PF18359
PH_hs_0023897
SETDB1
SETDB1-201
SETDB1-202
SETDB1-205
SM00317
SM00333
SM00391
SM00468
TC01001194.hg
TC01004737.hg
UPI000002B372
UPI0000135897
UPI0000456250
X6R732
X6RHV1
XM_017002955
XP_016858444
Participant Of
hasComponent
ATF7IP:SETDB1 [nucleoplasm]
input
ATF7IP binds SETDB1
Inferred To
SETDB1 [nucleoplasm] (Bos taurus)
SETDB1 [nucleoplasm] (Canis familiaris)
SETDB1 [nucleoplasm] (Danio rerio)
SETDB1 [nucleoplasm] (Drosophila melanogaster)
SETDB1 [nucleoplasm] (Gallus gallus)
SETDB1 [nucleoplasm] (Mus musculus)
SETDB1 [nucleoplasm] (Rattus norvegicus)
SETDB1 [nucleoplasm] (Sus scrofa)
SETDB1 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_001138887.1
,
XP_016858444.1
,
NP_036564.3
,
NP_001230420.1
ZINC - Metabolites
SETB1_HUMAN
ZINC - World Drugs
SETB1_HUMAN
OpenTargets
ENSG00000143379
ZINC - Substances
SETB1_HUMAN
GeneCards
Q15047
ZINC - Biogenic
SETB1_HUMAN
ZINC target
Q15047
PRO
Q15047
ZINC - Predictions - Purchasable
SETB1_HUMAN
HMDB Protein
HMDBP00411
PDB
5KCH
,
5KE2
,
6BHE
,
5KCO
,
6BHI
,
6BHD
,
6BPI
,
5QT1
,
4X3S
,
6AU3
,
5QT2
,
5KE3
,
3DLM
,
6BHH
,
5KH6
,
6BHG
,
6AU2
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31749 AKT1
13
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
0.639
9
UniProt:Q9Y6K1 DNMT3A
2
DNMT3A [nucleoplasm]
(R-HSA-212287)
SUMO1-K-DNMT3A [nucleoplasm]
(R-HSA-4655415)
0.61
7
UniProt:Q9UIS9 MBD1
2
MBD1 [nucleoplasm]
(R-HSA-417134)
SUMO1-K499,K538-MBD1 [nucleoplasm]
(R-HSA-4090331)
0.581
3
UniProt:Q99549 MPP8
0.564
3
UniProt:Q9H9J2 MRPL44
1
MRPL44 [mitochondrial inner membrane]
(R-HSA-5368245)
0.553
2
UniProt:Q15714 T22D1
0.553
2
UniProt:P04183 TK1
1
TK1 [cytosol]
(R-HSA-73500)
0.553
2
UniProt:P63279 UBE2I
8
SUMO1-C93-UBE2I [cytosol]
(R-HSA-4656909)
SUMO1-K14-UBE2I [nucleoplasm]
(R-HSA-4085358)
UBE2I [nuclear envelope]
(R-HSA-4655408)
UBE2I [cytosol]
(R-HSA-4655342)
SUMO3-C93-UBE2I [nucleoplasm]
(R-HSA-3730629)
SUMO2-C93-UBE2I [nucleoplasm]
(R-HSA-3730619)
UBE2I [nucleoplasm]
(R-HSA-912481)
SUMO1-C93-UBE2I [nucleoplasm]
(R-HSA-3730617)
0.553
2
UniProt:P11802 CDK4
3
CDK4 [nucleoplasm]
(R-HSA-113843)
p-T172-CDK4 [nucleoplasm]
(R-HSA-113830)
CDK4 [cytosol]
(R-HSA-68330)
0.553
2
UniProt:P02766 TTR
2
TTR [azurophil granule lumen]
(R-HSA-6799366)
TTR [extracellular region]
(R-HSA-976883)
0.553
2
UniProt:P61956 SUMO2
5
UBA2-G93-SUMO2 [nucleoplasm]
(R-HSA-3730618)
SUMO2(1-95) [nucleoplasm]
(R-HSA-2990837)
SUMO2 [nucleoplasm]
(R-HSA-2984281)
UBE2I-G93-SUMO2 [nucleoplasm]
(R-HSA-3730625)
MDC1-SUMO2 [nucleoplasm]
(R-HSA-5684062)
0.553
2
UniProt:Q6P1J9 CDC73
1
CDC73 [nucleoplasm]
(R-HSA-3322360)
0.524
3
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