Reactome | GRK2 sequesters activated Gq

GRK2 sequesters activated Gq

Stable Identifier

R-HSA-416516

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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GRK2 can inhibit GPCR signaling via phosphorylation-independent sequestration of Gq/11/14 subunits utilising its RGS homology (RH) domain. GRK2 may be an effector of activated Gq, initiating signalling cascades other than the classical PLC beta signalling associated with Gq.

Literature References

PubMed ID	Title	Journal	Year
16339447	Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex Shankaranarayanan, A, Tesmer, JJ, Kozasa, T, Tesmer, VM, Kawano, T	Science	2005
10727532	Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: direct interaction of kinase N terminus with activated galphaq Mariggiò, S, Sallese, M, D'Urbano, E, Iacovelli, L, De Blasi, A	Mol. Pharmacol.	2000
10567430	Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2 Sternweis, PM, Pronin, AN, Day, PW, Kozasa, T, Gilman, AG, Wedegaertner, PB, Carman, CV, Benovic, JL, Parent, JL	J Biol Chem	1999