EFNBs bind SDCBP

Stable Identifier
R-HSA-4093329
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Recruitment of syntenin 1 to presynaptic sites by binding to ephrinBs
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Activation of ephrin-B1 (EFNB1) and ephrin-B2 (EFNB2) by postsynaptic EPHB receptors initiates presynaptic differentiation and causes increases in the density of presynaptic release sites. The EPHB-EFNB interaction recruits the adaptor protein syntenin-1 (SDCBP) through the PDZ-binding domain of EFNBs. SDCBP colocalizes with EFNB1 and EFNB2 at synaptic contacts and knockdown of EFNBs leads to a reduction in the number of synaptic contacts. SDCBP provides a direct link by which EFNB can associate with a protein complex involved in the recruitment and regulation of presynaptic vesicles. McClelland et al. suggest a model whereby SDCBP recruits multidomain scaffolding molecules that enables the clustering of synaptic vesicles including ERC2/CAST1, RIM1 and Rab synaptic vesicle proteins (McClelland et al. 2009).

Literature References
PubMed ID Title Journal Year
19915143 Ephrin-B1 and ephrin-B2 mediate EphB-dependent presynaptic development via syntenin-1

McClelland, AC, Sheffler-Collins, SI, Kayser, MS, Dalva, MB

Proc. Natl. Acad. Sci. U.S.A. 2009
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