PIAS1,3 SUMOylate ESR1 with SUMO1

Stable Identifier
R-HSA-4090408
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PIAS1,3 SUMOylate ESR1 (Estrogen Receptor alpha, ER-alpha, ER, NR3A1) at lysines-266,268,299,302,303 with SUMO1 (Sentis et al. 2005). SUMOylation reduces transcription activation by ESR1.

Literature References
PubMed ID Title Journal Year
15961505 Sumoylation of the estrogen receptor alpha hinge region regulates its transcriptional activity

Sentis, S, Le Romancer, M, Bianchin, C, Rostan, MC, Corbo, L

Mol. Endocrinol. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS1,3 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created