SUMOylation of intracellular receptors

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R-HSA-4090294
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Pathway
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Homo sapiens
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At least 17 nuclear receptors have been discovered to be SUMOylated (reviewed in Treuter and Venteclef 2011, Wadosky et al. 2012, Knutson and Lange 2013). In all but a few cases (notably AR and RORA) SUMOylation causes transcriptional repression. Repression by SUMOylation is believed to occur through several mechanisms: interference with DNA binding, recruitment of corepressors, retention of corepressors at non-target promoters (transrepression), re-localization of nuclear receptors within the nucleus, interference with dimerization of receptors, and interference (crosstalk) with other post-translational modifications. SUMOylation of receptors affects inflammation and disease processes (Anbalagan et al. 2012).

Literature References
PubMed ID Title Journal Year
22037188 The story so far: post-translational regulation of peroxisome proliferator-activated receptors by ubiquitination and SUMOylation

Wadosky, KM, Willis, MS

Am. J. Physiol. Heart Circ. Physiol. 2012
23810010 Dynamic regulation of steroid hormone receptor transcriptional activity by reversible SUMOylation

Knutson, TP, Lange, CA

Vitam. Horm. 2013
21172431 Transcriptional control of metabolic and inflammatory pathways by nuclear receptor SUMOylation

Treuter, E, Venteclef, N

Biochim. Biophys. Acta 2011
22438791 Post-translational modifications of nuclear receptors and human disease

Anbalagan, M, Huderson, B, Murphy, L, Rowan, BG

Nucl Recept Signal 2012
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