PIAS1,3 SUMOylate MBD1 with SUMO1

Stable Identifier
R-HSA-4090288
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PIAS1,3 SUMOylates MBD1 at lysine-499 and lysine-538 of the reference sequence (lysine-450 and lysine-489 of isoform 5) with SUMO1 (Lyst et al. 2006, Uchimura et al. 2006). SUMOylated MBD1 does not form a complex with SETDB1 and does not repress transcription.

Literature References
PubMed ID Title Journal Year
16757475 Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation

Uchimura, Y, Ichimura, T, Uwada, J, Tachibana, T, Sugahara, S, Nakao, M, Saitoh, H

J. Biol. Chem. 2006
17066076 Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins

Lyst, MJ, Nan, X, Stancheva, I

EMBO J. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS1,3 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created