FOXM1 stimulates CCNB1 transcription

Stable Identifier
R-HSA-4088298
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
FOXM1 stimulates CCNB1 transcription
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
FOXM1 bound to the MuvB complex (consisting of LIN9, LIN37, LIN52, LIN54 and RBBP4) and MYBL2 (B-MYB) stimulates CCNB1 (cyclin B1) transcription (Laoukili et al. 2005, Sadasivam et al. 2012).
Literature References
PubMed ID Title Journal Year
15654331 FoxM1 is required for execution of the mitotic programme and chromosome stability

Kooistra, MR, Brás, A, Medema, RH, Clevers, HC, Kauw, J, Laoukili, J, Morrison, A, Kerkhoven, RM

Nat. Cell Biol. 2005
22391450 The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression

Duan, S, Sadasivam, S, DeCaprio, JA

Genes Dev. 2012
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-T611,S730,S739-FOXM1:MuvB:MYBL2:CCNB1 Gene [nucleoplasm] (Homo sapiens)
Active Unit
MuvB complex [nucleoplasm]
p-T611,S730,S739-FOXM1 [nucleoplasm]
MYBL2 [nucleoplasm]
Authored
Orlic-Milacic, M  (2013-08-14)
Reviewed
Bruinsma, W  (2013-08-21)
Created
Orlic-Milacic, M  (2013-08-12)
Cite Us!