FOXM1 binds CDC25A promoter

Stable Identifier
R-HSA-4088162
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Phosphorylated FOXM1 transcription factor binds the promoter of CDC25A gene and also recruits EP300 (p300) transcriptional coactivator to the promoter (Sullivan et al. 2012). While FOXM1 DNA binding may not depend on phosphorylation, the phosphorylation of the threonine residue T611 (T596 in FOXM1B isoform) is necessary for EP300 recruitment (Major et al. 2004).

Literature References
PubMed ID Title Journal Year
23240008 Novel interactions between FOXM1 and CDC25A regulate the cell cycle

Sullivan, C, Liu, Y, Shen, J, Curtis, A, Newman, C, Hock, JM, Li, X

PLoS ONE 2012
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Participant Of
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