PLK1 phosphorylates FOXM1

Stable Identifier
R-HSA-4088134
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PLK1 phosphorylates FOXM1 on serine residues S730 and S739 (S715 and S724 in FOXM1B isoform) in the C-terminal transactivation domain (TAD). PLK1-mediated phosphorylation of FOXM1 upregulates FOXM1 transcriptional activity and is crucial for FOXM1 function at G2/M transition (Fu et al. 2008).

Literature References
PubMed ID Title Journal Year
19160488 Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression

Fu, Z, Malureanu, L, Huang, J, Wang, W, Li, H, van Deursen, JM, Tindall, DJ, Chen, J

Nat. Cell Biol. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T611-FOXM1:p-T210-PLK1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed