PLK1 binds FOXM1

Stable Identifier
R-HSA-4088130
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PLK1 polo-box domain (PBD) binds a consensus sequence S-pS/pT-P/X in the transactivation domain (TAD) of FOXM1 after the threonine T611 (T596 in FOXM1B isoform) in this sequence is phosphorylated by cyclin-dependent kinase(s). PLK1 may also bind to another consensus site in the TAD of FOXM1, which involves CDK-phosphorylated serine S693 (S678 in FOXM1B isoform) (Fu et al. 2008).

Literature References
PubMed ID Title Journal Year
19160488 Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression

Fu, Z, Malureanu, L, Huang, J, Wang, W, Li, H, van Deursen, JM, Tindall, DJ, Chen, J

Nat. Cell Biol. 2008
Participants
Participant Of
Orthologous Events
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Reviewed