SUMOylation of NPM1 with SUMO1

Stable Identifier
R-HSA-4086088
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NPM1 (Nucleophosmin, B23) is SUMOylated at lysine-263 with SUMO1 (Liu et al. 2007). SUMOylation enhances binding of NPM1 to Rb and enhances nuclear residency of NPM1.

Literature References
PubMed ID Title Journal Year
17535915 Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival

Liu, X, Liu, Z, Jang, SW, Ma, Z, Shinmura, K, Kang, S, Dong, S, Chen, J, Fukasawa, K, Ye, K

Proc. Natl. Acad. Sci. U.S.A. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created