Laminin-111 binds endostatin dimer

Stable Identifier
R-HSA-4084507
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Laminin-111 binds endostatin dimer
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Endostatin is an anti-angiogenic and motility-inducing factor produced by proteolytic cleavage within the NC1 domain of collagen type XVIII. It is bound by all three short arms of laminin-111 (Javaherian et al. 2002). Laminin-111 complexes strongly with the NC1 trimeric domain or endostatin dimer, but only weakly with endostatin monomer.
Literature References
PubMed ID Title Journal Year
12237301 Laminin modulates morphogenic properties of the collagen XVIII endostatin domain

LaMontagne, KR, Javaherian, K, Lo, KM, Park, SY, Gillies, S, Pickl, WF, Sjin, RT

J. Biol. Chem. 2002
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Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2013-07-29)
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