Reactome | EHHADH [peroxisomal matrix]

EHHADH [peroxisomal matrix]

Stable Identifier

R-HSA-400155

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

Peroxisomal bifunctional enzyme

Locations in the PathwayBrowser for interactor UniProt:Q4V328 GRAP1

Expand all

Literature References

PubMed ID	Title	Journal	Year
1651711	Import of human bifunctional enzyme into peroxisomes of human hepatoma cells in vitro Chen, GL, Balfe, A, Erwa, W, Hoefler, G, Gaertner, J, Aikawa, J, Chen, WW	Biochem. Biophys. Res. Commun.	1991

External Reference Information

External Reference

UniProt:Q08426 EHHADH

Gene Names

EHHADH, ECHD

Chain

chain:1-723

Reference Genes

BioGPS Gene:1962 EHHADH

COSMIC (genes):EHHADH EHHADH

CTD Gene:1962 EHHADH

dbSNP Gene:1962 EHHADH

ENSEMBL:ENSG00000113790 EHHADH

HGNC:3247 EHHADH

KEGG Gene (Homo sapiens):1962 EHHADH

Monarch:1962 EHHADH

NCBI Gene:1962 EHHADH

OMIM:607037 EHHADH

UCSC:Q08426 EHHADH

Reference Transcript

Other Identifiers

0004780465

00062+4.2.1.17+1.1.1.35

00071+4.2.1.17+1.1.1.35

00071+5.1.2.3+4.2.1.17+1.1.1.35

00280+4.2.1.17+1.1.1.35

00281+4.2.1.17+1.1.1.35

00310+4.2.1.17+1.1.1.35

00360+4.2.1.17

00362+4.2.1.17+1.1.1.35

00380+4.2.1.17+1.1.1.35

00410+4.2.1.17

00592+4.2.1.17

00623+1.1.1.35

00627+4.2.1.17

00640+4.2.1.17

00650+4.2.1.17+1.1.1.35

00650+5.1.2.3+4.2.1.17+1.1.1.35

00720+4.2.1.17+1.1.1.35

00903+4.2.1.17

00930+4.2.1.17+1.1.1.35

11724039_at

11724040_at

11747115_a_at

16962277

1962

205222_at

2708721

2708722

2708723

2708724

2708725

2708726

2708727

2708731

2708732

2708733

2708736

2708745

2708748

2708749

2708758

2708760

31871_r_at

36401

42021

8092523

A_24_P123119

AAA53289

AAB19482

AAH38948

AAI10461

AC007934

AC128680

AJ427345

AJ427346

AJ427347

AJ427348

AJ427349

AJ427350

AJ427351

AK223460

AK291798

AK301521

BAD97180

BAF84487

BAG63025

BC038948

BC110460

C9JJE0

CAD22483

CCDS33901

CCDS54694

CH471052

EAW78229

EAW78230

EHHADH

EHHADH-201

EHHADH-203

ENSG00000113790

ENSP00000231887

ENSP00000387746

ENST00000231887

ENST00000231887.7

ENST00000456310

ENST00000456310.5

EntrezGene:1962

EntrezGene:EHHADH

g4503496_3p_at

GE57572

GO:0003674

GO:0003824

GO:0003857

GO:0004165

GO:0004300

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005777

GO:0005782

GO:0005829

GO:0006464

GO:0006475

GO:0006605

GO:0006625

GO:0006629

GO:0006631

GO:0006635

GO:0006810

GO:0008150

GO:0008152

GO:0009056

GO:0015031

GO:0016491

GO:0016508

GO:0016829

GO:0016853

GO:0019899

GO:0033540

GO:0043226

GO:0044281

GO:0055114

HGNC:3247

HPA036401

HPA042021

ILMN_1701507

ILMN_1751877

IPR001753

IPR006108

IPR006176

IPR006180

IPR008927

IPR018376

IPR029045

IPR036291

L07077

L07077_at

MIM:607037

MIM:615605

NM_001166415

NM_001966

NP_001159887

NP_001957

PF00378

PF00725

PF02737

PH_hs_0025237

S50245

TC03002076.hg

UPI000013C959

UPI00017A802D

XM_006713525

XP_006713588

Participant Of

hasMember

Cargo proteins containing PTS1 [peroxisomal matrix]

Other forms of this molecule

EHHADH [cytosol]

Inferred To

EHHADH [peroxisomal matrix] (Bos taurus)

EHHADH [peroxisomal matrix] (Caenorhabditis elegans)

EHHADH [peroxisomal matrix] (Canis familiaris)

EHHADH [peroxisomal matrix] (Danio rerio)

EHHADH [peroxisomal matrix] (Gallus gallus)

EHHADH [peroxisomal matrix] (Mus musculus)

EHHADH [peroxisomal matrix] (Rattus norvegicus)

EHHADH [peroxisomal matrix] (Sus scrofa)

EHHADH [peroxisomal matrix] (Xenopus tropicalis)

Cross References

RefSeq

NP_001159887.1, XP_011510819.1, NP_001957.2

OpenTargets

ENSG00000113790

IntEnz

5.3.3.8, 1.1.1.35

GeneCards

Q08426

PRO

Q08426

Orphanet

17357

HMDB Protein

HMDBP00380

Interactors (93)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8WV44 TRIM41	1	TRIM41 [cytosol] (R-HSA-5688975)	0.764	6
UniProt:O15344 MID1	1	MID1 [cytosol] (R-HSA-976027)	0.764	7
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.696	5
UniProt:Q96C00 ZBTB9			0.696	5
UniProt:P17661 DES	1	DES [cytosol] (R-HSA-390570)	0.696	5
UniProt:P35520 CBS	1	PXLP-K119-CBS [cytosol] (R-HSA-1614563)	0.666	4
UniProt:P63261 ACTG1	3	ACTG1 [cytosol] (R-HSA-201858) ACTG1 [lysosomal membrane] (R-HSA-196169) ACTG1 [plasma membrane] (R-HSA-196044)	0.666	4
UniProt:Q68D86 C102B			0.666	4
UniProt:P29144 TPP2	1	TPP2 [cytosol] (R-HSA-983068)	0.666	5
UniProt:O43805 SSNA1	1	SSNA1 [cytosol] (R-HSA-380255)	0.666	4
UniProt:Q8NC69 KCTD6	1	KCTD6 [cytosol] (R-HSA-8863321)	0.666	5
UniProt:Q8IVP5 FUNDC1	4	p-S13,Y18-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934915) p-S17-FUNDC1 [mitochondrial outer membrane] (R-HSA-8948140) FUNDC1 [mitochondrial outer membrane] (R-HSA-8934922) p-S13-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934910)	0.666	4
UniProt:Q15025 TNIP1	1	TNIP1 [cytosol] (R-HSA-5690853)	0.666	4
UniProt:Q7L273 KCTD9			0.666	4
UniProt:P60709 ACTB	5	ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [plasma membrane] (R-HSA-196016) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [lysosomal membrane] (R-HSA-196160)	0.621	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:Q8ND90 PNMA1			0.556	3
UniProt:Q7Z6G3-2 NECAB2			0.556	3
UniProt:Q1KLZ0 Q1KLZ0			0.556	3
UniProt:Q9Y2D8 ADIP			0.556	3
UniProt:Q9BYV2 TRI54			0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.556	3
UniProt:Q13077 TRAF1	3	TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1 [cytosol] (R-HSA-5634163) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:Q8IYE1 CCD13			0.488	2
UniProt:Q8N2N9-4 ANKRD36B			0.488	2
UniProt:Q53FP2 TM35A			0.488	2
UniProt:Q8TEZ7 PAQR8			0.488	2
UniProt:P56856 CLDN18	2	CLDN18 [cell junction] (R-HSA-434607) CLDN18 [plasma membrane] (R-HSA-432972)	0.488	2
UniProt:Q9NS64 RPRM			0.488	2
UniProt:Q9BZL4 PP12C			0.488	2
UniProt:Q08AM6 VAC14	3	VAC14 [early endosome membrane] (R-HSA-1806207) VAC14 [late endosome membrane] (R-HSA-1806219) VAC14 [Golgi membrane] (R-HSA-1806235)	0.488	2
IntAct:EBI-12904486 DAAM2			0.488	2
UniProt:Q8IV36 HID1			0.488	2
UniProt:Q9BTD3 TM121			0.488	2
UniProt:P78563-4 ADARB1			0.488	2
UniProt:Q16585 SGCB			0.488	2
UniProt:Q5JR59-3 MTUS2			0.488	2
UniProt:Q8N3Y7 SDR16C5	1	RDHE2 [endoplasmic reticulum membrane] (R-HSA-5621649)	0.488	2
UniProt:Q96IK5 GMCL1			0.488	2
UniProt:P80188 LCN2	2	LCN2 [extracellular region] (R-HSA-5215934) LCN2 [specific granule lumen] (R-HSA-6799614)	0.488	2
UniProt:Q86X19 TMM17			0.488	2
UniProt:P54849 EMP1			0.488	2
UniProt:O95214 LERL1			0.488	2
UniProt:Q9NP94 SLC39A2	1	SLC39A2 [plasma membrane] (R-HSA-442395)	0.488	2
UniProt:Q15849 SLC14A2	1	SLC14A2 [plasma membrane] (R-HSA-444115)	0.488	2
UniProt:O14684 PTGES	1	PTGES [endoplasmic reticulum membrane] (R-HSA-2142717)	0.488	2
UniProt:O43586 PSTPIP1	1	PSTPIP1 [cytosol] (R-HSA-879220)	0.488	2
UniProt:Q96BR9 ZBT8A			0.488	2
UniProt:Q8N5M9 JAGN1			0.488	2
UniProt:Q96RE7 NACC1			0.488	2
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.488	2
UniProt:Q4V328 GRAP1			0.488	2
UniProt:O00291 HIP1	1	HIP1 [cytosol] (R-HSA-8868153)	0.488	2
UniProt:Q9UH62 ARMX3			0.488	2
UniProt:Q9BUP3-3 HTATIP2			0.488	2
UniProt:Q9NQ48 LZTFL1	1	LZTFL1 [cytosol] (R-HSA-5617789)	0.488	2
UniProt:Q96PV4 PNMA5			0.488	2
UniProt:Q71RC9 SMIM5			0.488	2
UniProt:Q86X02 CDR2L			0.488	2
UniProt:Q9Y592-2 CEP83			0.488	2
UniProt:Q9NP64 NO40			0.488	2
UniProt:Q13838 DDX39B	1	DDX39B [nucleoplasm] (R-HSA-8849139)	0.488	2
UniProt:Q96DT7-3 ZBTB10			0.488	2
UniProt:P35372-10 OPRM1			0.488	2
UniProt:Q8N8X9 MB213			0.488	2
UniProt:Q9HCK0 ZBT26			0.488	2
UniProt:Q9C035-3 TRIM5			0.488	2
UniProt:Q92915-2 FGF14			0.488	2
UniProt:O75569 PRKRA	1	PRKRA [cytosol] (R-HSA-2399897)	0.488	2
UniProt:P36406 TRI23			0.488	2
UniProt:Q04864-2 REL			0.488	2
UniProt:Q9NX76 CMTM6	3	CMTM6 [plasma membrane] (R-HSA-6806275) CMTM6 [azurophil granule membrane] (R-HSA-6799141) CMTM6 [specific granule membrane] (R-HSA-6800916)	0.488	2
IntAct:EBI-12003048 TMEM31			0.488	2
UniProt:P49760 CLK2			0.488	2
UniProt:Q96GQ5 RUS1			0.488	2
UniProt:Q9P0S3 ORMDL1	1	ORMDL1 [endoplasmic reticulum membrane] (R-HSA-8865584)	0.488	2
UniProt:Q8N9W6-4 BOLL			0.488	2
UniProt:Q9BYQ6 KRTAP4-11	1	KRTAP4-11 [cytosol] (R-HSA-6809960)	0.488	2
UniProt:O75208 COQ9	1	COQ9 [mitochondrial inner membrane] (R-HSA-8932994)	0.488	2
UniProt:Q6ZMJ2-2 SCARA5			0.488	2
UniProt:Q16637 SMN1	2	SMN1 [cytosol] (R-HSA-191839) SMN1 [nucleoplasm] (R-HSA-191892)	0.488	2
UniProt:O43761 SNG3			0.488	2
UniProt:Q8N5K1 CISD2			0.488	2
UniProt:P55072 VCP	8	VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [nucleoplasm] (R-HSA-5643745) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [secretory granule lumen] (R-HSA-6801039) VCP [extracellular region] (R-HSA-6806191) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [cytosol] (R-HSA-1181251)	0.488	2
UniProt:Q969Q1 TRIM63	1	TRIM63 [cytosol] (R-HSA-976020)	0.488	2
UniProt:Q5JTZ9 AARS2	1	AARS2 [mitochondrial matrix] (R-HSA-379653)	0.488	2
UniProt:P19474 TRIM21	1	TRIM21 [cytosol] (R-HSA-976051)	0.488	2
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.488	2
UniProt:O00501 CLDN5	2	CLDN5 [plasma membrane] (R-HSA-419991) CLDN5 [cell junction] (R-HSA-421264)	0.488	2
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.488	2
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.488	2
UniProt:Q8NBQ5 HSD17B11	1	HSD17B11 [cytosol] (R-HSA-5693370)	0.488	2