Reactome | DAAM1 recruits PFN1

DAAM1 recruits PFN1

Stable Identifier

R-HSA-3965450

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The FH1 domain of DAAM1 recruits Profilin1 (PFN1) to the DVL:DAAM1 complex, and DAAM1 and PFN1 colocalize at stress fibers in response to WNT signaling (Sato et al, 2006). In addition to binding to FH domains, Profilin proteins bind to monomeric actin and in this way serve as a source of actin for polymerization of unbranched actin chains (Birbach, 2008; Goode and Eck, 2007). Depletion of PFN1 inhibits stress fiber formation in response to WNT signaling but does not affect DAAM1-mediated RHO A activation. In vivo, PFN1 is required downstream of DAAM1 for blastopore closure in Xenopus (Sato et al, 2006). In another study, PFN2 was also identified as an FH1 domain-interacting partner of DAAM1. The roles of PFN1 and PFN2 appear to be non-overlapping, however, as PFN2 is not required for blastopore closure in Xenopus but instead contributes to convergent extension (Khadka et al, 2009).

Literature References

PubMed ID	Title	Journal	Year
17373907	Mechanism and function of formins in the control of actin assembly Eck, MJ, Goode, BL	Annu. Rev. Biochem.	2007
19523939	Non-redundant roles for Profilin2 and Profilin1 during vertebrate gastrulation Khadka, DK, Habas, R, Liu, W	Dev. Biol.	2009
18798527	Profilin, a multi-modal regulator of neuronal plasticity Birbach, A	Bioessays	2008
17021034	Profilin is an effector for Daam1 in non-canonical Wnt signaling and is required for vertebrate gastrulation Runnels, LW, Bharti, R, Dawid, IB, Sato, A, Khadka, DK, Habas, R, Liu, W	Development	2006