SFKs phosphorylate NGEF

Stable Identifier
R-HSA-3928648
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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SFKs phosphorylate NGEF
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Activation of EPHAs leads to phosphorylation of ephexin1 (NGEF) on conserved tyrosine (Y) 179 (Y87 in isoform3) by Src family kinases (SFKs). This phosphorylation preferentially activates NGEF’s GDP/GTP exchange activity specifically towards RHOA but not RAC1 and CDC42, thus switching the substrate preference of NGEF and leading to actin cytoskeletal changes that result in growth cone collapse (Sahin et al. 2005, Knoll and Drescher 2004).
Participants
Input
Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of EFNAs:p-EPHAs:SFKs:NGEF [plasma membrane]

Physical Entity
EFNAs:p-EPHAs:SFKs:NGEF [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Phosphorylation of ephexin1 (Gallus gallus)
Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-07-22)
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