EPHB phosphorylates TIAM1

Stable Identifier
R-HSA-3928627
Type
Reaction
Species
Homo sapiens
Compartment
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Once recruited to the EPHB:NMDAR complex, T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1) is phosphorylated on tyrosine 829 by either EPHB or a kinase that associates with activated EPHB. TIAM1 may then activate Rac1, leading to actin cytoskeletal remodelling required for spine development and morphogenesis (Tolias et al. 2007).

Literature References
PubMed ID Title Journal Year
17440041 The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development

Tolias, KF, Bikoff, JB, Kane, CG, Tolias, CS, Hu, L, Greenberg, ME

Proc. Natl. Acad. Sci. U.S.A. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
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