PAKs autophosphorylate

Stable Identifier
R-HSA-3928625
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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General
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PAK is also locally activated in the synapse. PAK1 needs autophosphorylation for complete activation. PAK1 is autophosphorylated at several sites, but serine 144 (S144) in the GTPase-binding domain and threonine 423 (T423) in the activation loop are the two conserved sites that regulate the catalytic activity (Bokoch 2003).
Literature References
PubMed ID Title Journal Year
12676796 Biology of the p21-activated kinases

Bokoch, GM

Annu. Rev. Biochem. 2003
15800193 A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC

Webb, DJ, Zhang, H, Horwitz, AF, Asmussen, H, Niu, S

J. Neurosci. 2005
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane]

Orthologous Events
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