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SFKs phosphorylate GIT1
Stable Identifier
R-HSA-3928594
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
Ephrin signaling (Homo sapiens)
SFKs phosphorylate GIT1 (Homo sapiens)
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G-protein-coupled receptor kinase-interacting protein 1 (GIT1) has been shown to be critical for spine morphogenesis and synapse formation through assembling and targeting multiprotein signaling complexes, which contain important actin regulators including PIX, Rac GEF, and PAK, between the sub-cellular compartments (Zhang et al. 2003). Activation of ephrinBs (EFNBs) by EPHB receptors may lead to the phosphorylation of GIT1 on Tyr392 (in humans Tyr385, based on sequence similarity). The Src-family kinases (SFKs) recruited to EFNB expression domains are involved in this phosphorylation. Tyr392 in the N-terminal of the SLD domain is required for GIT1s binding to the SH2 domain of GRB4 (Segura et al. 2007).
Participants
Input
ATP [cytosol]
GIT1 [cytosol]
(Homo sapiens)
Output
ADP [cytosol]
p-Y383-GIT1 [cytosol]
(Homo sapiens)
Entity On Other Cell
EPHBs [plasma membrane]
(Homo sapiens)
Participates
as an event of
Ephrin signaling (Homo sapiens)
Catalyst Activity
protein tyrosine kinase activity of EPHBs:EFNBs:SRC,FYN [plasma membrane]
Physical Entity
EPHBs:EFNBs:SRC,FYN [plasma membrane]
(Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
SFKs phosphorylate Git1 (Mus musculus)
Authored
Garapati, P V (2013-07-23)
Reviewed
Ip, NY (2014-05-19)
Created
Garapati, P V (2013-07-22)
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