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p-Y383-GIT1 [cytosol]
Stable Identifier
R-HSA-3928463
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
phospho-GIT1
Locations in the PathwayBrowser for interactor UniProt:O43504 LAMTOR5
Expand all
Developmental Biology (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
Ephrin signaling (Homo sapiens)
EFNB:GRB4 binds GIT1 (Homo sapiens)
p-Y383-GIT1 [cytosol] (Homo sapiens)
SFKs phosphorylate GIT1 (Homo sapiens)
p-Y383-GIT1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y2X7 GIT1
Gene Names
GIT1
Chain
chain:1-761
Reference Genes
BioGPS Gene:28964 GIT1
COSMIC (genes):GIT1 GIT1
CTD Gene:28964 GIT1
dbSNP Gene:28964 GIT1
ENSEMBL:ENSG00000108262 GIT1
HGNC:4272 GIT1
KEGG Gene (Homo sapiens):28964 GIT1
Monarch:28964 GIT1
NCBI Gene:28964 GIT1
OMIM:608434 GIT1
UCSC:Q9Y2X7 GIT1
Reference Transcript
RefSeq:NM_014030.3 GIT1
RefSeq:NM_001085454.1 GIT1
Other Identifiers
0004230372
11717653_a_at
11752140_x_at
11754464_x_at
16842999
218030_at
28964
3751542
3751543
3751544
3751546
3751547
3751549
3751550
3751551
3751552
3751553
3751554
3751556
3751557
3751558
3751559
3751560
3751561
3751563
3751566
3751567
3751568
3751569
3751571
3751572
3751576
3751577
4059
4186
43805_f_at
65952_at
8013923
A0A0C4DGN6
A_23_P100912
A_24_P347946
A_33_P3401673
AAD28046
AAH06227
AAH48196
AC104564
AF124490
AK294785
AK299932
BAG57910
BAG61765
BC006227
BC048196
CCDS11250
CCDS42290
E7EVC2
ENSG00000108262
ENSP00000225394
ENSP00000378338
ENST00000225394
ENST00000225394.7
ENST00000394869
ENST00000394869.7
EntrezGene:28964
EntrezGene:GIT1
g7661711_3p_at
g7661711_3p_x_at
GE58546
GIT1
GIT1-201
GIT1-203
GO:0003674
GO:0005096
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005829
GO:0005925
GO:0006810
GO:0007049
GO:0007165
GO:0007267
GO:0008150
GO:0008277
GO:0016020
GO:0016192
GO:0030234
GO:0032465
GO:0043167
GO:0043547
GO:0044305
GO:0044877
GO:0046872
GO:0048013
GO:0051301
GO:0099171
GO:2000300
HGNC:4272
HPA004059
HPA004186
ILMN_1733155
IPR001164
IPR002110
IPR013724
IPR020683
IPR022018
IPR032352
IPR036770
IPR037278
IPR038508
J3QL89
J3QLH1
J3QRU8
K7EIX6
K7EN79
MIM:608434
NM_001085454
NM_014030
NP_001078923
NP_054749
PF01412
PF08518
PF12205
PF12796
PF16559
PH_hs_0024106
PR00405
SM00105
SM00248
SM00555
TC17001320.hg
UPI000013C867
UPI0000E59EEC
XM_011524684
XM_011524685
XM_024450731
XM_024450732
XM_024450733
XM_024450734
XP_011522986
XP_011522987
XP_024306499
XP_024306500
XP_024306501
XP_024306502
Participant Of
output
SFKs phosphorylate GIT1
input
EFNB:GRB4 binds GIT1
hasComponent
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane]
Other forms of this molecule
GIT1 [cytosol]
Inferred To
phospho-p-Y383-GIT1 [cytosol] (Bos taurus)
phospho-p-Y383-GIT1 [cytosol] (Caenorhabditis elegans)
phospho-p-Y383-GIT1 [cytosol] (Canis familiaris)
phospho-p-Y383-GIT1 [cytosol] (Danio rerio)
phospho-p-Y383-GIT1 [cytosol] (Drosophila melanogaster)
phospho-p-Y383-GIT1 [cytosol] (Gallus gallus)
phospho-p-Y383-GIT1 [cytosol] (Mus musculus)
phospho-p-Y383-GIT1 [cytosol] (Rattus norvegicus)
phospho-p-Y383-GIT1 [cytosol] (Sus scrofa)
phospho-p-Y383-GIT1 [cytosol] (Xenopus tropicalis)
Modified Residues
Name
O4'-phospho-L-tyrosine at 383
Coordinate
383
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001078923.1
,
NP_054749.2
OpenTargets
ENSG00000108262
GeneCards
Q9Y2X7
PRO
Q9Y2X7
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14155 ARHGEF7
1
ARHGEF7 [cytosol]
(R-HSA-430346)
0.702
4
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.669
4
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
0.669
3
UniProt:Q13153 PAK1
6
p-S144-PAK1 [cytosol]
(R-HSA-451339)
Active PAK1 [cytosol]
(R-HSA-8964622)
PAK1 [plasma membrane]
(R-HSA-3928409)
p-S144,T423-PAK1 [plasma membrane]
(R-HSA-3928472)
PAK1 [cytosol]
(R-HSA-162629)
p-S144,T423-PAK1 [cytosol]
(R-HSA-399819)
0.669
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.602
10
UniProt:O60925 PFDN1
1
PFDN1 [cytosol]
(R-HSA-379541)
0.553
2
UniProt:P41220 RGS2
1
RGS2 [plasma membrane]
(R-HSA-939787)
0.553
2
UniProt:P30519 HMOX2
3
HMOX2 [endoplasmic reticulum membrane]
(R-HSA-189391)
HMOX2 [plasma membrane]
(R-HSA-6799676)
HMOX2 [specific granule membrane]
(R-HSA-6799628)
0.553
2
UniProt:Q9H7E9 CH033
0.553
2
UniProt:O43504 LAMTOR5
1
LAMTOR5 [lysosomal membrane]
(R-HSA-5655441)
0.553
2
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.547
2
UniProt:Q9P2H0 CE126
0.508
2
UniProt:Q5T3J3 LRIF1
0.508
2
UniProt:Q99728 BARD1
2
BARD1 [nucleoplasm]
(R-HSA-5659775)
p-T714,T734-BARD1 [nucleoplasm]
(R-HSA-5659846)
0.508
2
UniProt:Q12873 CHD3
2
SUMO1-K1971-CHD3 [nucleoplasm]
(R-HSA-8956372)
CHD3 [nucleoplasm]
(R-HSA-4657012)
0.508
2
UniProt:P49024 PAXI
0.499
3
UniProt:P25098 GRK2
4
p-S29-ADRBK1 [plasma membrane]
(R-HSA-111969)
GRK2 [plasma membrane]
(R-HSA-50270)
ADRBK1 [cilium]
(R-HSA-5632504)
p-S29-ADRBK1 [cytosol]
(R-HSA-9645318)
0.463
5
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