Reactome | Activation of EPACs by cAMP

Activation of EPACs by cAMP

Stable Identifier

R-HSA-392834

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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EPACs (exchange proteins directly activated by cAMP) are Rap1 GEFs that are activated by direct binding of cAMP (cyclic adenosine monophosphate). cAMP-GEFI (EPAC1) is widely expressed, while cAMP-GEFII (EPAC2) is enriched in brain and adrenal tissue. Both are selective for Rap1. A role of EPACs has been proposed for Rap1-dependent cell adhesion to laminin in both epithelial and red blood cells, and in the regulation of vascular endothelial barrier function.

Literature References

PubMed ID	Title	Journal	Year
9789079	A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia Mochizuki, N, Graybiel, AM, Housman, DE, Canales, JJ, Matsuda, M, Blumenstiel, JP, Chen, EJ, Toki, S, Harlan, P, Kawasaki, H, Bany, IA, Ashbacher, A, Springett, GM	Proc Natl Acad Sci U S A	1998