PRC1 SUMOylates CASP8AP2 with SUMO1

Stable Identifier
R-HSA-3927824
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Pc2 SUMOylates FLASH
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The CBX3 component of PRC1 SUMOylates CASP8AP2 (FLASH) at lysine-1813 with SUMO1 (Alm-Kristiansen et al. 2009). SUMOylation enhances the transcriptional coactivation activity of CASP8AP2. SUMOylation also appears to trigger proteasomal degradation of CASP8AP2 (Vennemann and Hofmann 2013).

Literature References
PubMed ID Title Journal Year
19615980 SUMO modification regulates the transcriptional activity of FLASH

Alm-Kristiansen, AH, Norman, IL, Matre, V, Gabrielsen, OS

Biochem. Biophys. Res. Commun. 2009
23673342 SUMO regulates proteasome-dependent degradation of FLASH/Casp8AP2

Vennemann, A, Hofmann, TG

Cell Cycle 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PRC1 complex [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created