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Nitric oxide stimulates guanylate cyclase
Stable Identifier
R-HSA-392154
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Nitric oxide stimulates guanylate cyclase (Homo sapiens)
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Nitric Oxide (NO) inhibits smooth muscle cell proliferation and migration, oxidation of low-density lipoproteins, and platelet aggregation and adhesion. It can stimulate vasodilatation of the endothelium, disaggregation of preformed platelet aggregates and inhibits activated platelet recruitment to the aggregate. NO is synthesized from L-arginine by a family of isoformic enzymes known as nitric oxide synthase (NOS). Three isoforms, namely endothelial, neuronal, and inducible NOS (eNOS, nNOS, and iNOS, respectively), have been identified. The eNOS isoform is found in the endothelium and platelets. NO regulation of cyclic guanosine-3,5-monophosphate (cGMP), via activation of soluble guanylate cyclase, is the principal mechanism of negative control over platelet activity. Defects in this control mechanism have been associated with platelet hyperaggregability and associated thrombosis.
Literature References
PubMed ID
Title
Journal
Year
12881475
Regulation of nitric oxide-sensitive guanylyl cyclase
Koesling, D
,
Friebe, A
Circ Res
2003
Participants
Events
Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)
(Homo sapiens)
NO binds to Guanylate Cyclase
(Homo sapiens)
Soluble guanylate cyclase converts GTP to cGMP
(Homo sapiens)
cGMP effects
(Homo sapiens)
Participates
as an event of
Platelet homeostasis (Homo sapiens)
Orthologous Events
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Nitric oxide stimulates guanylate cyclase (Dictyostelium discoideum)
Nitric oxide stimulates guanylate cyclase (Drosophila melanogaster)
Nitric oxide stimulates guanylate cyclase (Gallus gallus)
Nitric oxide stimulates guanylate cyclase (Mus musculus)
Nitric oxide stimulates guanylate cyclase (Plasmodium falciparum)
Nitric oxide stimulates guanylate cyclase (Rattus norvegicus)
Nitric oxide stimulates guanylate cyclase (Saccharomyces cerevisiae)
Nitric oxide stimulates guanylate cyclase (Schizosaccharomyces pombe)
Nitric oxide stimulates guanylate cyclase (Sus scrofa)
Nitric oxide stimulates guanylate cyclase (Xenopus tropicalis)
Authored
Akkerman, JW (2009-06-03)
Reviewed
Kunapuli, SP (2010-06-07)
Created
Jupe, S (2009-02-27)
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