Reactome | EP2 and EP4 receptors can bind PGE2

EP2 and EP4 receptors can bind PGE2

Stable Identifier

R-HSA-391940

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Eicosanoid ligand-binding receptors (Homo sapiens)
        
        Prostanoid ligand receptors (Homo sapiens)
        
        EP2 and EP4 receptors can bind PGE2 (Homo sapiens)

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Once activated by PGE2, the EP2 (Regan JW et al, 1994) receptor:ligand complex can mediate downstream effects by coupling to the G protein alpha s subunit and activate adenylyl cyclase (Schwaner I et al, 1995). EP4 receptors (Bastien L et al, 1994) are present on smooth muscle cells and their effects are mediated via coupling to G protein alpha s subunit and subsequent stimulation of adenylate cyclase (Wilson RJ et al, 2004).

Literature References

PubMed ID	Title	Journal	Year
7532011	Differential activation of Gi and Gs proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL Schultz, G, Offermanns, S, Spicher, K, Seifert, R, Schwaner, I	Biochim Biophys Acta	1995
15464062	Functional pharmacology of human prostanoid EP2 and EP4 receptors Wilson, RJ, Gray, DW, Rhodes, SA, Noel, LS, Wood, RL, Giles, H, Shield, VJ	Eur J Pharmacol	2004
8163486	Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype Bastien, L, Adam, M, Sawyer, N, Metters, KM, Grygorczyk, R	J Biol Chem	1994
8078484	Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype Pepperl, DJ, Pierce, KL, Regan, JW, Gil, DW, Kedzie, KM, Donello, JE, Woodward, DF, Fairbairn, CE, Bogardus, AM, Bailey, TJ	Mol Pharmacol	1994