Reactome | 5-HT4, 6 and 7 receptors can bind serotonin

5-HT4, 6 and 7 receptors can bind serotonin

Stable Identifier

R-HSA-390931

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Serotonin receptors (Homo sapiens)
        
        5-HT4, 6 and 7 receptors can bind serotonin (Homo sapiens)

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5-HT4, 6 and 7 receptors can bind serotonin

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The 5-HT4 receptor (Van den Wyngaert I et al, 1997) is located in the alimentary tract, bladder, heart and adrenal gland as well as the central nervous system (CNS). It modulates the release of various neurotransmitters. Multiple transcripts encode proteins with distinct C-terminal sequences, but the full-length nature of some transcript variants has not been determined (Blondel O et al, 1998). The 5-HT6 receptor (Kohen R et al, 1996) is primarily expressed in the brain and is involved in glutamatergic and cholinergic neuronal activity. The 5-HT7 receptor (Stam NJ et al, 1997) plays a role in vasculature smooth muscle relaxation and in the GI tract. It is involved in thermoregulation, circadian rhythm, learning and memory, and sleep.
All these receptor types mediate their actions by coupling to the G protein alpha-s subtype, which increases cellular cAMP levels (Baker LP et al, 1998; Zhang JY et al, 2003).

Literature References

PubMed ID	Title	Journal	Year
9651336	Stimulation of type 1 and type 8 Ca2+/calmodulin-sensitive adenylyl cyclases by the Gs-coupled 5-hydroxytryptamine subtype 5-HT7A receptor Baker, LP, Metcalf, MA, Obrietan, K, Storm, DR, Impey, S, Chan, G, Poser, SW, Nielsen, MD, Hamblin, MW	J Biol Chem	1998
12860470	Characterization of the 5-HT6 receptor coupled to Ca2+ signaling using an enabling chimeric G-protein Dunlop, J, Schechter, L, Smith, D, Zhang, JY, Spangler, T, Kowal, D, Ochalski, R, Nawoschik, S	Eur J Pharmacol	2003
9349523	Cloning and expression of a human serotonin 5-HT4 receptor cDNA Luyten, W, Van den Wyngaert, I, Jurzak, M, Gommeren, W, Verhasselt, P, Leysen, J, Bender, E	J Neurochem	1997
9603189	Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus Dahmoune, Y, Blondel, O, Fischmeister, R, Gastineau, M, Langlois, M	J Neurochem	1998
9303561	Human serotonin 5-HT7 receptor: cloning and pharmacological characterisation of two receptor variants Dijcks, F, van Herpen, A, Garritsen, A, Olijve, W, Roesink, C, Stam, NJ	FEBS Lett	1997
8522988	Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor Sibley, DR, Meltzer, HY, Khan, N, Roth, BL, Metcalf, MA, Lachowicz, JE, Kohen, R, Huebner, K, Druck, T, Hamblin, MW	J Neurochem	1996