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FYB [cytosol]
Stable Identifier
R-HSA-390925
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ADAP, FYN-binding protein, SLAP-130
Locations in the PathwayBrowser for interactor UniProt:P16333 NCK1
Expand all
Cell-Cell communication (Homo sapiens)
Signal regulatory protein family interactions (Homo sapiens)
p-4Y-SIRPA:CD47:SKAP2 binds FYB (Homo sapiens)
FYB [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
TCR signaling (Homo sapiens)
Generation of second messenger molecules (Homo sapiens)
p-SLP-76 binds ADAP (Homo sapiens)
FYB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15117 FYB1
Gene Names
FYB, SLAP130, FYB1
Chain
chain:1-783
Reference Genes
BioGPS Gene:2533 FYB
COSMIC (genes):FYB FYB
CTD Gene:2533 FYB
dbSNP Gene:2533 FYB
ENSEMBL:ENSG00000082074 FYB
HGNC:4036 FYB
KEGG Gene (Homo sapiens):2533 FYB
Monarch:2533 FYB
NCBI Gene:2533 FYB
OMIM:602731 FYB
UCSC:O15117 FYB
Reference Transcript
RefSeq:XM_006714464.2 FYB
RefSeq:XM_006714466.2 FYB
RefSeq:NM_001465.4 FYB
RefSeq:XM_011514010.1 FYB
RefSeq:XM_011514009.1 FYB
RefSeq:NM_001243093.1 FYB
RefSeq:XM_011514008.2 FYB
RefSeq:XM_006714465.2 FYB
RefSeq:NM_199335.3 FYB
Other Identifiers
0002690451
11724004_a_at
11724005_s_at
11730372_a_at
11730373_a_at
11730374_a_at
16995601
1RI9
205285_s_at
211794_at
211795_s_at
227266_s_at
2533
25336
26796
2854328
2854329
2854330
2854332
2854333
2854335
2854336
2854338
2854340
2854343
2854345
2854349
2854355
2854368
2854369
2854370
2854371
2854385
2854407
2GTJ
2GTO
41819_at
55978_at
61712_at
74675_s_at
8111739
A_23_P122127
A_24_P393740
AAB62226
AAC51300
AAF62400
AAI17450
AAI43646
AC008964
AC010633
AC025471
AF001862
AF198052
AK290403
AK297077
BAF83092
BAG59594
BC117449
BC143645
CAB025336
CCDS47200
CCDS54848
CCDS58945
CH471119
D6RAE8
D6RC38
D6RER7
D6RFJ5
EAW55984
ENSG00000082074
ENSP00000316460
ENSP00000425845
ENSP00000426346
ENSP00000493623
ENST00000351578
ENST00000351578.11
ENST00000505428.5
ENST00000512982
ENST00000512982.3
ENST00000515010
ENST00000515010.5
ENST00000646045
EntrezGene:2533
EntrezGene:FYB1
FYB1
FYB1-201
FYB1-208
FYB1-209
FYB1-212
g7416992_3p_a_at
GE81027
GO:0002376
GO:0003674
GO:0005102
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0006955
GO:0007165
GO:0007229
GO:0008150
GO:0008289
GO:0015629
GO:0030054
GO:0032991
GO:0043226
GO:0044877
GO:0050852
GO:0072659
HGNC:4036
HPA026796
Hs.34192.1.A1_3p_at
Hs.58435.0.S1_3p_a_at
ILMN_1785504
ILMN_1796537
ILMN_2280548
IPR001452
IPR029294
IPR030635
IPR035540
IPR036028
MIM:273900
MIM:602731
NM_001243093
NM_001349333
NM_001465
NM_018594
NM_199335
NP_001230022
NP_001336262
NP_001456
NP_061064
NP_955367
PF07653
PF14603
PH_hs_0023383
SM00326
TC05001295.hg
TC05002968.hg
U93049
U93049_at
UPI000020C9D5
UPI000020C9D6
UPI00017A75FB
XM_006714464
XM_006714466
XM_011514008
XM_011514009
XM_011514010
XM_011514011
XM_011514012
XP_006714527
XP_006714529
XP_011512310
XP_011512311
XP_011512312
XP_011512313
XP_011512314
Participant Of
hasComponent
p-SLP-76:ADAP [cytosol]
p-Y428,Y452,Y469,Y495-SIRPA:CD47:SKAP2:FYB [plasma membrane]
input
p-4Y-SIRPA:CD47:SKAP2 binds FYB
p-SLP-76 binds ADAP
Inferred To
FYB [cytosol] (Bos taurus)
FYB [cytosol] (Canis familiaris)
FYB [cytosol] (Danio rerio)
FYB [cytosol] (Gallus gallus)
FYB [cytosol] (Mus musculus)
FYB [cytosol] (Rattus norvegicus)
FYB [cytosol] (Sus scrofa)
Cross References
RefSeq
NP_955367.1
,
XP_006714528.1
,
NP_001456.3
,
XP_011512312.1
,
XP_011512310.1
,
XP_006714527.1
,
XP_006714529.1
,
NP_001230022.1
,
XP_011512311.1
GeneCards
O15117
PRO
O15117
Orphanet
25600
PDB
1RI9
,
2GTJ
,
2GTO
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13094 LCP2
2
p-Y113,128,145-LCP2 [cytosol]
(R-HSA-202175)
LCP2 [cytosol]
(R-HSA-202306)
0.904
11
UniProt:P06241 FYN
6
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
p-Y420-FYN [cytosol]
(R-HSA-391821)
FYN [cytosol]
(R-HSA-200917)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
0.819
7
UniProt:Q86WV1 SKAP1
0.729
6
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.621
3
UniProt:P16333 NCK1
2
NCK1 [cytosol]
(R-HSA-197954)
NCK1 [plasma membrane]
(R-HSA-202992)
0.564
3
UniProt:O60880 SH2D1A
1
SH2D1A [cytosol]
(R-HSA-5685108)
0.527
2
UniProt:P06241-3 FYN
0.488
2
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