SUMOylation of MKL1 with SUMO1

Stable Identifier
R-HSA-3900070
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MKL1 is SUMOylated with SUMO1 at lysine-499, lysine-576, and lysine-624 (Nakagawa and Kuzumaki 2005) SUMOylation represses transcriptional activity of MKL1. MKL1 is a coactivator of SRF.

Literature References
PubMed ID Title Journal Year
16098147 Transcriptional activity of megakaryoblastic leukemia 1 (MKL1) is repressed by SUMO modification

Nakagawa, K, Kuzumaki, N

Genes Cells 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created