SUMOylation of DDX17 with SUMO1

Stable Identifier
R-HSA-3900047
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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DDX17 is SUMOylated at lysine-50 with SUMO1 or SUMO2 (Mooney et al. 2010, Fuller-Pace and Nicol 2012, Impens et al. 2014). SUMOylation reduces the transactivation activity of DDX17 with the estrogen receptor and with p53. SUMOylation also promotes association of DDX17 with HDAC1.

Literature References
PubMed ID Title Journal Year
19995069 Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential

Mooney, SM, Grande, JP, Salisbury, JL, Janknecht, R

Biochemistry 2010
22713328 DEAD-box RNA helicases as transcription cofactors

Fuller-Pace, FV, Nicol, SM

Meth. Enzymol. 2012
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Radoshevich, L, Cossart, P, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created