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HCRTR2 [plasma membrane]
Stable Identifier
R-HSA-389421
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Orexin receptor 2, RecName: Full=Orexin receptor type 2; AltName: Full=Ox2r; AltName: Full=Hypocretin receptor type 2;
GN Name=HCRTR2;
OS Homo sapiens, OX2R_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HCRTR2:HCRT(70-97) [plasma membrane] (Homo sapiens)
HCRTR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HCRTR2:HCRT(70-97) [plasma membrane] (Homo sapiens)
HCRTR2 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HCRTR2:HCRT(70-97) [plasma membrane] (Homo sapiens)
HCRTR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HCRTR2:HCRT(70-97) [plasma membrane] (Homo sapiens)
HCRTR2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
HCRTR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
HCRTR2:HCRT(70-97) [plasma membrane] (Homo sapiens)
HCRTR2 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Orexin and neuropeptides FF and QRFP bind to their respective receptors (Homo sapiens)
Orexin 2 receptor can bind orexin-B neuropeptide (Homo sapiens)
HCRTR2 [plasma membrane] (Homo sapiens)
HCRTR2:HCRT(70-97) [plasma membrane] (Homo sapiens)
HCRTR2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43614 HCRTR2
Gene Names
HCRTR2
Chain
chain:1-444
Reference Genes
BioGPS Gene:3062 HCRTR2
COSMIC (genes):HCRTR2 HCRTR2
CTD Gene:3062 HCRTR2
dbSNP Gene:3062 HCRTR2
ENSEMBL:ENSG00000137252 HCRTR2
ENSEMBL_homo_sapiens_GENE:ENSG00000137252.10 HCRTR2
HGNC:4849 HCRTR2
Monarch:3062 HCRTR2
NCBI Gene:3062 HCRTR2
OMIM:602393 HCRTR2
Reference Transcript
RefSeq:NM_001526.4 HCRTR2
Other Identifiers
11756777_a_at
17009766
207393_PM_at
207393_at
2911004
2911005
2911006
2911013
2911014
2911015
2911019
2911021
2911022
2911024
2911025
2911026
2911027
3062
33072_at
8120342
A_14_P114312
GE80035
GO:0004930
GO:0005515
GO:0005886
GO:0007165
GO:0007186
GO:0007200
GO:0007218
GO:0007268
GO:0007631
GO:0008188
GO:0010840
GO:0016020
GO:0016499
GO:0017046
GO:0022410
GO:0023052
GO:0032870
GO:0040011
GO:0042277
GO:0045202
GO:0051480
GO:0055065
GO:0060089
HMNXSV003044381
ILMN_1678065
PH_hs_0009137
TC06000677.hg
g6006037_3p_at
Participates
as an input of
Orexin 2 receptor can bind orexin-B neuropeptide (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
as a component of
HCRTR2:HCRT(70-97) [plasma membrane] (Homo sapiens)
Inferred To
hcrtr [plasma membrane]
(Danio rerio)
Hcrtr2 [plasma membrane]
(Mus musculus)
Hcrtr2 [plasma membrane]
(Rattus norvegicus)
HCRTR2 [plasma membrane]
(Bos taurus)
HCRTR2 [plasma membrane]
(Canis familiaris)
HCRTR2 [plasma membrane]
(Gallus gallus)
HCRTR2 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001517.2
ZINC - World Drugs
OX2R_HUMAN
Guide to Pharmacology - Targets
322
OpenTargets
ENSG00000137252
ZINC - FDA approved
OX2R_HUMAN
ZINC - Substances
OX2R_HUMAN
ZINC target
O43614
PRO
O43614
PDB
7L1V
,
4S0V
,
7SQO
,
7XRR
,
7L1U
,
6TPJ
,
5WQC
,
6TPN
,
7SR8
,
5WS3
,
6TPG
ZINC - Investigational
OX2R_HUMAN
HPA
ENSG00000137252-HCRTR2
GeneCards
O43614
Ensembl
ENSG00000137252
,
ENSP00000477548
,
ENST00000370862
,
ENSP00000359899
,
ENST00000615358
Pharos - Targets
O43614
ZINC - Predictions - Purchasable
OX2R_HUMAN
HMDB Protein
HMDBP14443
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62937 PPIA
5
PPIA [extracellular exosome]
(R-HSA-6801538)
PPIA [secretory granule lumen]
(R-HSA-6801400)
PPIA [ficolin-1-rich granule lumen]
(R-HSA-6801391)
PPIA [cytosol]
(R-HSA-173123)
PPIA [extracellular region]
(R-HSA-173646)
0.556
3
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