Reactome | SMARCE1 [nucleoplasm]

SMARCE1 [nucleoplasm]

Stable Identifier

R-HSA-389258

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

BAF57

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
        
        RUNX1 binds the SWI/SNF complex (Homo sapiens)
        
        RUNX1:CBFB:SWI/SNF [nucleoplasm] (Homo sapiens)
        
        SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
        
        SWI/SNF additional components [nucleoplasm] (Homo sapiens)
        
        SMARCE1 [nucleoplasm] (Homo sapiens)
        
        SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
        
        SWI/SNF additional components [nucleoplasm] (Homo sapiens)
        
        SMARCE1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q969G3 SMARCE1

Gene Names

SMARCE1, BAF57

Chain

chain:1-411

Reference Genes

BioGPS Gene:6605 SMARCE1

COSMIC (genes):SMARCE1 SMARCE1

CTD Gene:6605 SMARCE1

dbSNP Gene:6605 SMARCE1

ENSEMBL:ENSG00000073584 SMARCE1

ENSEMBL_homo_sapiens_GENE:ENSG00000073584.20 SMARCE1

HGNC:11109 SMARCE1

KEGG Gene (Homo sapiens):6605 SMARCE1

Monarch:6605 SMARCE1

NCBI Gene:6605 SMARCE1

OMIM:603111 SMARCE1

UCSC:Q969G3 SMARCE1

Reference Transcript

RefSeq:NM_003079.4 SMARCE1

Other Identifiers

11718772_at

11718773_s_at

11718774_s_at

11752770_a_at

11754075_s_at

11761728_a_at

16844386

16844406

211988_PM_at

211988_at

211989_PM_at

211989_at

236016_PM_at

236016_at

2963127

33828_at

3487942

3756345

3756346

3756347

3756348

3756349

3756350

3756351

3756352

3756353

3756355

3756356

3756358

3756363

3756364

3756365

3756371

3756375

3756376

3756378

3756379

3756380

3756381

3756382

6605

74367_at

77132_at

8015037

8015039

A_23_P164387

A_23_P333063

A_32_P20221

GE558638

GE79213

GO:0000228

GO:0000278

GO:0000776

GO:0000785

GO:0002376

GO:0003677

GO:0003682

GO:0003713

GO:0003723

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006281

GO:0006325

GO:0006337

GO:0006338

GO:0006351

GO:0006355

GO:0006357

GO:0007059

GO:0007155

GO:0007399

GO:0008080

GO:0016363

GO:0016514

GO:0016586

GO:0016740

GO:0016922

GO:0022008

GO:0030071

GO:0030154

GO:0031492

GO:0032991

GO:0035060

GO:0043226

GO:0045582

GO:0045597

GO:0045663

GO:0045892

GO:0045893

GO:0048856

GO:0070316

GO:0071564

GO:0071565

GO:0140092

GO:0140110

GO:1902459

GO:2000045

GO:2000781

GO:2000819

HMNXSV003012363

Hs.127211.0.A1_3p_at

Hs.332848.0.S1_3p_at

Hs.332848.0.S2_3p_at

ILMN_1747857

PH_hs_0030249

PH_hs_0033412

TC17002900.hg

Participates

as a component of

BAF complex [nucleoplasm] (Homo sapiens)

as a candidate of

SWI/SNF additional components [nucleoplasm] (Homo sapiens)

Inferred To

smarce1 [nucleoplasm] (Xenopus tropicalis)

swsn-3 [nucleoplasm] (Caenorhabditis elegans)

SMARCE1 [nucleoplasm] (Bos taurus)

SMARCE1 [nucleoplasm] (Canis familiaris)

SMARCE1 [nucleoplasm] (Dictyostelium discoideum)

SMARCE1 [nucleoplasm] (Gallus gallus)

SMARCE1 [nucleoplasm] (Sus scrofa)

Bap111 [nucleoplasm] (Drosophila melanogaster)

Smarce1 [nucleoplasm] (Mus musculus)

Smarce1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_003070.3

OpenTargets

ENSG00000073584

HPA

ENSG00000073584-SMARCE1

GeneCards

Q969G3

Ensembl

ENST00000644701, ENST00000643318, ENST00000647508, ENSP00000496097, ENSP00000496445, ENST00000447024, ENSP00000496094, ENSP00000392958, ENSG00000073584, ENSP00000367039, ENSP00000411607, ENST00000348513, ENST00000264640, ENSP00000494771, ENST00000578044, ENSP00000464511, ENST00000400122, ENST00000377808, ENSP00000323967, ENSP00000466608, ENST00000643683

PRO

Q969G3

Pharos - Targets

Q969G3

Orphanet

22035

PDB

7Y8R, 7CYU, 6LTJ, 6LTH, 7VDV

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.781	7
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.643	4
UniProt:Q9BXU0 TEX12	1	TEX12 [nucleoplasm] (R-HSA-912441)	0.556	3
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.556	3
UniProt:Q13099 IFT88	8	IFT88 [ciliary tip] (R-HSA-5625371) PolyUb-Misfolded IFT88 [late endosome lumen] (R-HSA-9660031) IFT88 [cilium] (R-HSA-5610385) PolyUb-Misfolded IFT88 [lysosomal lumen] (R-HSA-9660026) PolyUb-Misfolded IFT88 [cytosol] (R-HSA-9641125) Ub-Misfolded IFT88 [cytosol] (R-HSA-9641114) Misfolded IFT88 [cytosol] (R-HSA-9640115) Misfolded IFT88 [cilium] (R-HSA-9640106)	0.556	3
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.556	3
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.556	3
UniProt:Q9UPT5 EXOC7	2	EXOC7 [plasma membrane] (R-HSA-2872288) EXOC7 [cytosol] (R-HSA-5623386)	0.556	5
UniProt:Q8N0S2 SYCE1	1	SYCE1 [nucleoplasm] (R-HSA-912456)	0.556	3
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.483	2
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.462	2